6947-74-6

Basic information

• Product Name: 1-(naphthalen-1-ylmethyl)piperidine
• Synonyms: 1-(1-Naphthylmethyl)piperidine; piperidine, 1-(1-naphthalenylmethyl)-
• CAS NO: 6947-74-6
• Molecular Formula: C₁₆H₁₉N
• Molecular Weight: 225.3288
• Mol File: 6947-74-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 347.8°C at 760 mmHg
• Flash Point: 148.5°C
• Density: 1.073g/cm³
• Vapor Pressure: 5.25E-05mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 1-(naphthalen-1-ylmethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(naphthalen-1-ylmethyl)piperidine(6947-74-6)
• EPA Substance Registry System: 1-(naphthalen-1-ylmethyl)piperidine(6947-74-6)

Safety Data

• Hazardous Substances Data: 6947-74-6(Hazardous Substances Data)

Usage

Chemical structure

A piperidine derivative containing a naphthalene group

Usage

Commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds

Potential applications

Studied for its potential use in the treatment of neurological and psychiatric disorders, analgesic and anti-inflammatory properties, and synthesis of novel organic molecules with unique properties

Safety and toxicology

Limited information available, caution advised when handling and using the compound

Upstream product

• 5454-14-8 (naphthalen-1-yl)(piperidin-1-yl)methanone 
• 1268340-93-7 N-(trifluoroboratomethyl)piperidine internal salt 
• 68211-49-4 1-naphthyl tosylate 
• 38262-42-9 1-naphthyl mesylate 
• 110-89-4 piperidine 
• 86-52-2 1-Chloromethylnaphthalene 

Relevant articles and documents

Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines

PdII-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C-H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield. This journal is

Zinc-catalyzed chemoselective reduction of tertiary and secondary amides to amines

General and convenient procedures for the catalytic hydrosilylation of secondary and tertiary amides under mild conditions have been developed. In the presence of inexpensive zinc catalysts, tertiary amides are easily reduced by applying monosilanes. Key to success for the reduction of the secondary amides is the use of zinc triflate and disilanes with dual Si-H moieties. The presented hydrosilylations proceed with excellent chemoselectivity in the presence of sensitive ester, nitro, azo, nitrile, olefins, and other functional groups, thus making the method attractive for organic synthesis.