69470-09-3

Basic information

• Product Name: N-tert-butyloxycarbonyl-L-phenylalanyl-L-proline amide
• CAS NO: 69470-09-3
• Molecular Weight: 361.441
• Mol File: 69470-09-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-tert-butyloxycarbonyl-L-phenylalanyl-L-proline amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyloxycarbonyl-L-phenylalanyl-L-proline amide(69470-09-3)
• EPA Substance Registry System: N-tert-butyloxycarbonyl-L-phenylalanyl-L-proline amide(69470-09-3)

Safety Data

• Hazardous Substances Data: 69470-09-3(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 7531-52-4 L-prolinamide 
• 50903-54-3 N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine pentafluorophenyl ester 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 71989-31-6 Fmoc-Pro-OH 
• 147-85-3 L-proline 
• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 
• 23420-32-8 N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 

Downstream Products

• 88888-75-9 N-(benzyloxycarbonyl)-L-γ-methylglutamyl-L-phenylalanyl-L-prolinamide 
• 69461-91-2 Z-pGlu-Phe-Pro-NH₂ 
• 34783-35-2 L-pyroglutamyl-L-phenylalanine-L-proline amide 
• 83871-05-0 phenylalanylproline amide hydrochloride 

Relevant articles and documents

Structure and conformation of the tripeptide: N-t-Boc-Prolyl-Phenylalanyl-Proline (Boc-Pro-Phe-Pro)

The structure and conformation of the tripeptide N-t-Boc-Prolyl-Phenylalanyl-Proline (Boc-Pro-Phe-Pro) (C24H33N3O6) have been investigated with X-ray crystallographic and spectroscopic methods.Two conformations of Boc-Pro-Phe-Pro crystallized in the space

NOVEL THIAZINE OR PYRAZINE DERIVATIVES

An object of the present invention is to synthesize novel compounds having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine or 2-oxo-1, 2, 3, 4-tetrahydropyrazine as a main skeleton. The present invention relates to compounds represented by the following general formula [I] and salts thereof. In the formula, X is S or R6-(A2)n-N, R1 and R2 are H, alkyl, cycloalkyl or aryl, R3 and R4 are H, alkyl, cycloalkyl, aryl or aromatic heterocycles, R5 is H, alkyl, cycloalkyl, aryl or -A3-A4-R7, R6 is H, alkyl, cycloalkyl, OH, alkoxy, aryl, aryloxy or an aromatic heterocycle, R7 is H, alkyl, OH, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, an aromatic heterocycle or a nonaromatic heterocycle, A1 is alkylene, A2 is carbonyl or sulfonyl, A3 is alkylene, and A4 is carbonyl or oxalyl.

Synthesis and biological activity of branched enkephalin analogues

The synthesis and biological activity of a new type of enkephalin analogs are reported. A series of branched pentapeptides of the enkephalin sequence with replacement of 2-glycine by D-ornithine and branching of the peptide chain in position 2 by attachment of proline, leucine, asparagine or methionine residues to the 8-amino group of D-ornithine were synthesized by classical solution methodology. Analgesic activity of the new analogs was assayed by the 'tail pinch' method following intracisternal and intravenous administrations to mice. They showed higher analgesic potency and longer duration of action as compared to linear and cyclic pentapeptides with the same amino acid composition. The activity determined in the GPI and MVD bioassays, and in a binding assay, revealed the preference of the branched analogs for the μ-type of opioid receptor over the δ-type. These results raise the possibility to synthesize enkephalin analogs with high analgesic potency and opiate receptor selectivity by varying the chemical character and length of the side chain in the 2-position.