69478-75-7

Basic information

• Product Name: 3-(DIMETHYLAMINO)PYRROLIDINE
• Synonyms: AKOS BB-9268;3-(DIMETHYLAMINO)PYRROLIDINE;Dimethlaminopyrrolidine;3-(DIMETHYLAMINO)PYRROLIDINE 98+%;N,N-dimethylpyrrolidin-3-amine;3-(Dimethylamino)pyrrolidine dihydrochloride;N,N-Dimethyl-3-pyrrolidinamine
• CAS NO: 69478-75-7
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.19
• Product Categories: 3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic)
• Mol File: 69478-75-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 164 °C
• Flash Point: 54.5 °C
• Appearance: /
• Density: 0.9
• Refractive Index: 1.4640-1.4670
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.93±0.10(Predicted)
• CAS DataBase Reference: 3-(DIMETHYLAMINO)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)PYRROLIDINE(69478-75-7)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)PYRROLIDINE(69478-75-7)

Safety Data

• Hazard Codes: Xn
• Statements: 10-34-22
• Safety Statements: 26-36/37/39
• RIDADR: 2734
• HazardClass: 8/3
• PackingGroup: II
• Hazardous Substances Data: 69478-75-7(Hazardous Substances Data)

Usage

General Description

3-(Dimethylamino)pyrrolidine is a chemical compound with the molecular formula C7H14N2. It is a clear, colorless liquid with a boiling point of 148-151°C. This chemical is widely used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its role as a reagent for the preparation of a variety of heterocyclic compounds and is also used as a catalyst in organic reactions. Additionally, 3-(dimethylamino)pyrrolidine has been studied for its potential use in the treatment of central nervous system disorders and as a chiral ligand in asymmetric catalysis. It is important to handle this chemical with care, as it can be harmful if not used properly.

Downstream Products

• 361346-46-5 [1-(4-nitrophenyl)-pyrrolidin-3-yl] dimethylamine 
• 919088-54-3 3-chloro-4-[3-(3-dimethylamino-pyrrolidin-1-yl)-propoxy]-benzaldehyde 
• 1150308-93-2 [1-(2-chloro-5-nitro-benzyl)-pyrrolidin-3-yl]-dimethylamine 
• 1422389-68-1 C₁₉H₂₁ClN₄O₃ 
• 402948-34-9 [1-(3-amino-4-nitrophenyl)pyrrolidin-3-yl]dimethylamine 
• 947149-13-5 [1-(2-chloro-4-nitrophenyl)pyrrolidin-3-yl]dimethylamine 
• 861846-02-8 4-(3-dimethylamino-pyrrolidin-1-yl)-N-hydroxy-benzamidine 
• 861845-95-6 4-(3-dimethylamino-pyrrolidin-1-yl)-benzoic acid ethyl ester 

Relevant articles and documents

FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR

Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.

Dibenzo-epines: Effect of the basic side-chain on neuroleptic activity

Structure-activity relationships in a series of dibenzo[b,f][1,4]thiazepines and -oxazepines and dibenzo[b,e][1,4]diazepines having different basic substituents in the 11-position were studied with reference to their neuroleptic activity. A high degree of structure-specificity was found for the piperazinyl moiety as well as for the distances between the distal nitrogen atom of this group and the tricyclic ring system, which distances are probably of importance for receptor binding. It was shown that the N-oxides of the neuroleptic agents clotiapine, loxapine and clozapine were inactive in in vitro binding tests involving central dopaminergic receptors, and it is very likely therefore that the in vivo activity of these N-oxides in the rat is due to their enzymatic reduction to the active parent compounds. All derivatives having a basic side-chain other than N-alkylpiperazinyl were inactive neuroleptically, with the exception of the N-methyl-4-piperidyl derivative which showed relatively weak effects.