69500-64-7

Basic information

• Product Name: (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE
• Synonyms: (S) 2-AMINOMETHYLPYRROLIDINE;(S)-(+)-2-(AMINOMETHYL)PYRROLIDINE;(2S)-PYRROLIDIN-2-YL-METHYLAMINE;(S)-(+)-2-(Aminomethyl)pyrrolidine,98%;(S)-(+)-(Aminomethyl)pyrrolidine;(S)-pyrrolidin-2-ylMethanaMine;(2S)-2-Pyrrolidinemethanamine;(S)-2-Pyrrolidinemethanamine
• CAS NO: 69500-64-7
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• Product Categories: Chiral Compound;Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 69500-64-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 65 °C11 mm Hg(lit.)
• Flash Point: 117 °F
• Appearance: Clear colorless liquid
• Density: 0.933 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.42mmHg at 25°C
• Refractive Index: n20/D 1.482(lit.)
• PKA: 10.68±0.10(Predicted)
• CAS DataBase Reference: (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE(69500-64-7)
• EPA Substance Registry System: (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE(69500-64-7)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 3
• HazardClass: 8/3
• PackingGroup: II
• Hazardous Substances Data: 69500-64-7(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

(S)-(+)-2-(Aminomethyl)pyrrolidine can be used as an organocatalyst: For the asymmetric transformation of (S)-alanine. In the asymmetric α-fluorination of linear and branched aldehydes using N-fluorobenzenesulfonamide as the fluorinating agent.It can also be used as a reactant to prepare Schiff base metal complexes with pyrrolidine fragment as a ligand in asymmetric synthesis.

General Description

(S)-(+)-2-(Aminomethyl)pyrrolidine is a chiral vicinal diamine.

InChI:InChI=1/C5H12N2/c6-4-5-2-1-3-7-5/h5,7H,1-4,6H2/t5-/m0/s1

Upstream product

• 7531-52-4 L-prolinamide 
• 259537-92-3 tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate 
• 62937-47-7 (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 344-25-2 D-Prolin 
• 6404-31-5 Z-D-proline 
• 62937-45-5 (R)-prolinamide 
• 119020-01-8 (S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 782495-18-5 N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide 
• 69610-41-9 Boc-L-Pro-H 
• 204387-53-1 (2S)-pyrrolidine-2-carbonitrile 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 34079-31-7 Z-Pro-NH₂ 
• 147-85-3 L-proline 

Downstream Products

• 1206881-84-6 (S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-P,P-diphenylphosphinic amide 
• 956467-82-6 N-[((2R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-3,4-bis(methyloxy)benzenesulfonamide 
• 956467-79-1 N-[((2S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-N-methyl-3,4-bis(methyloxy)benzenesulfonamide 
• 1206103-64-1 (4aS,13aR)-8-bromo-10-[(phenylmethyl)oxy]-2,3,4a,5,13,13a-hexahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-9,11-dione 
• 1309561-99-6 (4aR,13aS)-N-[(2,4-difluorophenyl)methyl]-9,11-dioxo-10-[(phenylmethyl)oxy]-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazine-8-carboxamide 
• 122481-21-4 (-)-(S)-tetrahydro-1H-pyrrolo[1,2-c]imidazol-3(2H)-one 

Relevant articles and documents

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D -Prolyl-2-(trifluoromethylsulfonamidopropyl)pyrrolidine: An Organocatalyst for Asymmetric Michael Addition of Aldehydes to β-Nitroalkenes at Ambient Conditions

Four 2-(trifluoromethylsulfonamidoalkyl)pyrrolidines and their d-prolinamides were prepared and screened as organocatalysts for the Michael addition reaction of aldehydes with β-nitroalkenes at rt and without the use of additives. d-Prolyl-2-(trifluoromet

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.