695179-58-9

Basic information

• Product Name: 2-(3,4-dichloro-phenyl)-4-hydroxy-octanoic acid methyl ester
• CAS NO: 695179-58-9
• Molecular Weight: 319.228
• Mol File: 695179-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dichloro-phenyl)-4-hydroxy-octanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichloro-phenyl)-4-hydroxy-octanoic acid methyl ester(695179-58-9)
• EPA Substance Registry System: 2-(3,4-dichloro-phenyl)-4-hydroxy-octanoic acid methyl ester(695179-58-9)

Safety Data

• Hazardous Substances Data: 695179-58-9(Hazardous Substances Data)

Upstream product

• 1436-34-6 1,2-Epoxyhexane 
• 6725-44-6 methyl 2-(3,4-dichlorophenyl)acetate 

Relevant articles and documents

Synthesis and structure-antifungal activity relationships of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues: Further refinement of tentative pharmacophore group

Two series of 3-(substituted phenyl)-5-alkyl-2,5-dihydrofuran-2-ones related to a natural product, (-)incrustoporine, were synthesized and their in vitro antifungal activity evaluated. The compounds with halogen substituents on the phenyl ring exhibited selective antifungal activity against the filamentous strains of Absidia corymbifera and Aspergillus fumigatus. On the other hand, the influence of the lenghth of the alkyl chain at C(5) was marginal. The antifungal effect of the most active compound against the above strains was higher than that of ketoconazole, and close to that of amphotericin B. In order to verify the hypothesis about a possible relationship between the Michael-accepting ability of the compounds and their antifungal activity, a series of simple carbanalogues, 2-(substituted phenyl)cyclopent-2-enones, was prepared and subjected to antifungal activity assay as well.