69539-64-6

Basic information

• Product Name: Furo[3,2-b]pyridine-3-carboxylicacid,2-amino-,ethylester(9CI)
• Synonyms: Furo[3,2-b]pyridine-3-carboxylicacid,2-amino-,ethylester(9CI);ethyl 2-aminofuro[3,2-b]pyridine-3-carboxylate
• CAS NO: 69539-64-6
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.2
• Product Categories: AMINOACID
• Mol File: 69539-64-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 190-191 °C(Solv: benzene (71-43-2))
• Boiling Point: 324.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• PKA: 3.74±0.40(Predicted)
• CAS DataBase Reference: Furo[3,2-b]pyridine-3-carboxylicacid,2-amino-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,2-b]pyridine-3-carboxylicacid,2-amino-,ethylester(9CI)(69539-64-6)
• EPA Substance Registry System: Furo[3,2-b]pyridine-3-carboxylicacid,2-amino-,ethylester(9CI)(69539-64-6)

Safety Data

• Hazardous Substances Data: 69539-64-6(Hazardous Substances Data)

Upstream product

• 6602-28-4 3-hydroxypyridine N-oxide 
• 80465-04-9 2-hydroxy-2-ethoxy-3-cyano-4H-furo<3,2-b>pyridine 
• 64-17-5 ethanol 
• 69539-63-5 3-acetoxypyridine-2-malononitrile 
• 69539-66-8 2-amino-3-cyanofuro<3,2-b>pyridine 
• 69539-61-3 ethyl α-(3-acetoxypyridine-2)cyanoacetate 

Relevant articles and documents

FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Rearrangement of 2-Aminofuropyridine-3-carboxylic Esters

Ethyl 2-aminofuropyridine-3-carboxylate rearranges with sodium ethoxide in ethanol to 2-oxo-3-cyano-2,3-dihydrofuropyridine; the corresponding p-nitrophenyl ester undergoes the same rearrangement by dilute aqueous sodium hydroxide.In the first case it was possible to isolate the labile intermediate, which was shown to be the hemiacetal of the above mentioned cyanolactone.