6954-55-8

Basic information

• Product Name: 4-FLUORENECARBOXYLIC ACID TECH. 90
• Synonyms: 4-FLUORENECARBOXYLIC ACID TECH. 90;4-FLUORENECARBOXYLIC ACID, TECH., 90%;9-H-Fluorene-4-carboxylic acid, 99+ %;9H-Fluorene-4-carboxylic acid,96%
• CAS NO: 6954-55-8
• Molecular Formula: C₁₄H₁₀O₂
• Molecular Weight: 210.228
• EINECS: 230-138-9
• Product Categories: C13 to C42+;Carbonyl Compounds;Carboxylic Acids
• Mol File: 6954-55-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 179-182 °C(lit.)
• Boiling Point: 307.41°C (rough estimate)
• Flash Point: 191.2°C
• Appearance: /
• Density: 1.1597 (rough estimate)
• Vapor Pressure: 3.87E-08mmHg at 25°C
• Refractive Index: 1.5681 (estimate)
• PKA: 3.97±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 2050637
• CAS DataBase Reference: 4-FLUORENECARBOXYLIC ACID TECH. 90(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORENECARBOXYLIC ACID TECH. 90(6954-55-8)
• EPA Substance Registry System: 4-FLUORENECARBOXYLIC ACID TECH. 90(6954-55-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36/37/39-27
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6954-55-8(Hazardous Substances Data)

Usage

Chemical Properties

beige powder

Uses

Fluorene-4-carboxylic acid is used in pharmaceutical industry.

General Description

The structures of two phases of fluorene-4-carboxylic acid from room-temperature growths were studied.

InChI:InChI=1/C14H10O2/c15-14(16)12-7-3-5-10-8-9-4-1-2-6-11(9)13(10)12/h1-7H,8H2,(H,15,16)/p-1

Upstream product

• 6223-83-2 9-oxo-9H-fluorene-4-carboxylic acid 
• 7071-85-4 9-hydroxy-fluorene-4-carboxylic acid 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 863305-32-2 diphenic acid 

Downstream Products

• 7083-63-8 4-Aminofluorene 
• 7256-04-4 7-nitro-fluorene-4-carboxylic acid 
• 7145-76-8 5-nitro-fluorene-4-carboxylic acid 
• 7315-93-7 fluorene-4-carboxylic acid chloride 
• 6223-83-2 9-oxo-9H-fluorene-4-carboxylic acid 
• 1556-99-6 4-methylfluorene 
• 16218-33-0 2-Jod-fluoren-5-carbonsaeure 
• 141606-44-2 fluorene-4-carbonitrile 
• 99585-29-2 5-Hydroxy-2-nitrofluorene 
• 95303-05-2 2,4,5-Trichlorophenyl 9-(Hydroxymethyl)fluorene-4-carboxylate 
• 54147-65-8 5-nitrofluorenone-4-carboxylic acid 
• 7071-89-8 2,5-diaminofluorene 
• 403987-26-8 C₃₆H₃₇N₃O₂ 
• 403987-27-9 C₃₆H₃₇N₃O₂ 

Relevant articles and documents

A new base-labile anchoring group for polymer-supported peptide synthesis

-

Polymer-des-ethyl sunitinib conjugates

The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over des-ethyl sunitinib in unconjugated form.

Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7- and 9 -hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene

The metabolites of 2-nitrofluorene (NF), 5-, 7- and 9-OH-2-nitrofluorene (OH-NF) were compared for their genotoxicity. Seventy-two hours after intraperitoneal administration of these substances individually to rats (100 mg/kg body wt.), DNA adducts in liver tissue were analyzed with 32P-TLC and 32P-HPLC. An in vivo liver model was used to test the initiating capacity of the said substances for the formation of preneoplastic lesions. 5-OH-NF showed low capacity to induce DNA adduct formation and low potential as initiator to induce preneoplastic lesions-foci/nodules in the liver of rats. Both 7- and 9-OH-NF induced DNA adducts and preneoplastic liver lesions but with smaller quantities compared to NF. It seems that 7- and 9-OH-NF can not be considered as detoxification products of NF. In general, the initiating capacity of these substances for the formation of preneoplastic lesions has a good correlation with their potency to form DNA adducts.