6954-78-5

Basic information

• Product Name: 1-(3-BROMOPROPOXY)-2,4-DICHLOROBENZENE
• Synonyms: 1-(3-BROMOPROPOXY)-2,4-DICHLOROBENZENE;1-(3-Bromopropoxy)-2,4-dichlorobenzene,97%;1-(3-BroMopropoxy)-2,4-dichlorobenzene, 97% 5GR
• CAS NO: 6954-78-5
• Molecular Formula: C₉H₉BrCl₂O
• Molecular Weight: 283.98
• Mol File: 6954-78-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 170-174 °C (12 mmHg)
• Flash Point: 180 °C
• Appearance: /
• Density: 1.547g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-(3-BROMOPROPOXY)-2,4-DICHLOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOPROPOXY)-2,4-DICHLOROBENZENE(6954-78-5)
• EPA Substance Registry System: 1-(3-BROMOPROPOXY)-2,4-DICHLOROBENZENE(6954-78-5)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 6954-78-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to slightly yellow liquid

InChI:InChI=1/C9H9BrCl2O/c10-4-1-5-13-9-3-2-7(11)6-8(9)12/h2-3,6H,1,4-5H2

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 120-83-2 2,4-dichlorophenol 

Downstream Products

• 85507-24-0 N-methyl-3-(2,4-dichlorophenoxy)propylamine 
• 55247-57-9 Benzyl-[3-(2,4-dichloro-phenoxy)-propyl]-amine 
• 17780-72-2 clorgyline 
• 1421333-94-9 S-3-((3-(2,4-dichlorophenoxy)propyl)(prop-2-ynyl)amino)propane-1-thiol 
• 1421333-93-8 S-3-((3-(2,4-dichlorophenoxy)propyl)(prop-2-ynyl)amino)propyl ethanethioate 
• 1421333-92-7 N-(3-(2,4-dichlorophenoxy)propy)prop-2-yn-1-aminium 2,2,2-trifluoroacetate 
• 1421333-91-6 tert-butyl 3-(2,4-dichlorophenoxy)propyl(prop-2-ynyl)carbamate 
• 1421333-90-5 tert-butyl 3-(2,4-dichlorophenoxy)propylcarbamate 
• 1355026-29-7 C₁₅H₁₄Cl₂N₂O₄ 
• 287479-59-8 1-[3-(2,4-dichlorophenoxy)propyl]-1,2,3,6-tetrahydropyridine hydrochloride 
• 287479-51-0 1-[3-(2,4-dichlorophenoxy)propyl]-1,2,3,6-tetrahydropyridine 
• 1351938-87-8 1-(3-(2,4-dichlorophenoxy)propyl)pyridinium bromide 
• 50911-63-2 3-(2,4-dichlorophenoxy)propan-1-amine 
• 1052548-74-9 3-(2,4-dichlorophenoxy)propan-1-amine hydrochloride 

Relevant articles and documents

Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors

A novel series of dihydro-1,3,5-triazine derivatives bearing a heteroatom spiro-ring were designed and synthesized on the basis of molecular flexible docking work, and their biological activities were evaluated. Compounds A2, A5, B1 and B3 showed potent human dihydrofolate reductase (hDHFR) inhibitory activity with IC50values of 7.46 nM, 3.72 nM, 6.46 nM, 4.08 nM, versus reference drug methotrexate (MTX). From the molecular docking result we concluded that the conformation space generated by deformation of the flexible residue Phe31 is favorable for the binding of the spiro-ring, and inserting heteroatom into spiro ring might increase the binding affinity. There were 24 compounds with broadspectrum antiproliferative activity against several tumor cell lines (HCT116, A549, HL-60, HepG2 and MDA-MB-231) with IC50values ranging from 0.79 to 0.001 μM. The antitumor activity in?vivo of compound A2 was determined in a human alveolar basal epithelial cell line A549 xenograft model. This study offered novel anticancer agents with high inhibitory activity that target hDHFR and have a binding mode of the novel molecular scaffold with hDHFR. This provides potent support for further development of novel hDHFR inhibitors.

MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER

A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRN

Expeditious synthesis and biological evaluation of novel 2,N 6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as potential antimalarials

A small set of novel 2,N6-disubstituted 1,2-dihydro-1,3,5- triazine-4,6-diamines was prepared possessing a flexible tether between the exocyclic nitrogen bonded to C-6 of the 1,2-dihydro-1,3,5-triazine-4,6-diamine heterocycle and the distal ary