69557-55-7Relevant articles and documents
Heterocyclic compounds as inhibitors of factor VIIa
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Page/Page column 82; 83, (2008/06/13)
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
ONE ATOM LYNCH PIN TRANSFORMATIONS OF GOLD'S REAGENT
Gupton, John T.,Correia, Keith F.,Foster, Bruce S.
, p. 365 - 376 (2007/10/02)
A series of o-phenylenediamines and o-aminophenols have been reacted with Gold's reagent to yield benzimidazoles and benzoxazoles, respectively.Additionally, o-hydroxyacetophenone and anthranilamide, when reacted with Gold's reagent, were found to produce chromone and 3H-quinazoline-4-one, respectively.These transformations represent the use of Gold's reagent as a one atom lynch pin.