696-45-7 Usage
Description
4-Amino-6-methoxypyrimidine is an organic compound with the chemical formula C5H6N4O. It is a white to yellow powder and is used as a key intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
4-Amino-6-methoxypyrimidine is used as a key intermediate in the synthesis of carbamothiolacrylamides, which are selective EP2 antagonists. These compounds are used in the treatment of neurodegenerative peripheral diseases, such as diabetic neuropathy and postherpetic neuralgia.
Additionally, 4-Amino-6-methoxypyrimidine is used in the preparation of PARP-1 inhibitors. These inhibitors are being studied for their potential use in the treatment of various types of cancer, including breast, ovarian, and pancreatic cancers.
Overall, 4-Amino-6-methoxypyrimidine plays a crucial role in the development of new therapeutic agents for the treatment of various diseases, particularly in the pharmaceutical industry.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 15, p. 1121, 1978 DOI: 10.1002/jhet.5570150710
Check Digit Verification of cas no
The CAS Registry Mumber 696-45-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,9 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 696-45:
(5*6)+(4*9)+(3*6)+(2*4)+(1*5)=97
97 % 10 = 7
So 696-45-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3O/c1-9-5-2-4(6)7-3-8-5/h2-3H,1H3,(H2,6,7,8)
696-45-7Relevant articles and documents
Peptide deformylase inhibitors
-
Page/Page column, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
Novel procedure for selective C-nitrosation of aminopyrimidine derivatives under neutral conditions. Scope and synthetic applications
Marchal, Antonio,Melguizo, Manuel,Nogueras, Manuel,Sánchez, Adolfo,Low, John N.
, p. 255 - 258 (2007/10/03)
A novel simple method, based on treatment with isoamyl nitrite (IAN) in DMSO without any added acid, to produce selective C(5)-nitrosation of aminopyrimidine derivatives is described. It proved to be suitable for a multigram scale and applicable to a larger range of pyrimidine derivatives, including amino-dialkoxypyrimidines, than the procedures previously known. Its scope is analyzed and some example on the usefulness of the newly prepared substances as intermediates in the synthesis of fused heterobicyclic derivatives of potential biological interest is presented.