69626-75-1

Basic information

• Product Name: 2-Iodo-benzofuran
• Synonyms: 2-Iodo-benzofuran;2-iodo-1-benzofuran
• CAS NO: 69626-75-1
• Molecular Formula: C₈H₅IO
• Molecular Weight: 244.02917
• Mol File: 69626-75-1.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Iodo-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-benzofuran(69626-75-1)
• EPA Substance Registry System: 2-Iodo-benzofuran(69626-75-1)

Safety Data

• Hazardous Substances Data: 69626-75-1(Hazardous Substances Data)

Usage

General Description

2-Iodo-benzofuran, also known as 2-iodo-1-benzofuran, is a chemical compound with the molecular formula C8H5IO. It is a benzofuran derivative that contains an iodine atom attached to the benzene ring. 2-Iodo-benzofuran has several potential applications in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It is also a useful building block for the synthesis of various heterocyclic compounds. 2-Iodo-benzofuran is a versatile reagent that is widely used in the field of organic chemistry. It is important to handle this compound with care, as it is classified as a hazardous material and can pose risks to human health and the environment.

Upstream product

• 100124-06-9 4-dibenzofurylboronic acid 
• 98437-24-2 benzofuran-2-boronic acid 
• 402503-13-3 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan 
• 271-89-6 1-benzofurane 
• 496-41-3 Benzofuran-2-carboxylic acid 

Downstream Products

• 39165-03-2 2-ethynyl-1-benzofuran 
• 138118-26-0 2-[(E)-1-hexenyl]phenol 
• 66898-41-7 3-butyl-2H-chromen-2-one 
• 65715-20-0 2-(trifluoromethyl)benzofuran 
• 77234-10-7 2-(2phenylethynyl)benzo[b]furan 
• 205-39-0 benzo[b]naphtho[1,2-d]furan 
• 85960-75-4 (E)-2-(but-1-enyl)phenol 
• 1839-72-1 2-phenylbenzofuran 

Relevant articles and documents

Efficient synthesis of 5-oxatruxene and the unusual influence of oxygen heteroatom on its physico-chemical properties

In this paper, we describe the effective synthesis of oxatruxene and its photophysical, electrochemical and structural features that transpire when a methylene unit in a truxene core is replaced by an oxygen atom to yield 5-oxatruxene. This modification broke the C3h symmetry and at the same time introduced a more electronegative structure as revealed by a four-fold increase in the quantum yield as compared to truxene. The derivatives of this material have great potential in optoelectronic devices and in organic photovoltaics. This proposed new synthetic method can be used to introduce other heteroatoms into the truxene system.

Au(I)-Catalyzed Oxidative Functionalization of Yndiamides

Yndiamides, underexplored cousins of ynamides, offer rich synthetic potential as doubly nitrogenated two carbon building blocks. Here we report a gold-catalyzed oxidative functionalization of yndiamides to access unnatural amino acid derivatives, using a wide range of nucleophiles as a source of the amino acid side chain. The transformation proceeds under mild conditions, is highly functional group tolerant, and displays excellent regioselectivity through subtle steric differentiation of the yndiamide nitrogen atom substituents.

Copper-mediated aerobic iodination and perfluoroalkylation of boronic acids with (CF3)2CFI at room temperature

The copper-mediated aerobic reactions between the branched (CF3)2CFI and boronic acids (R-B(OH)2) are described. Different from the linear perfluoroalkyl analogs CF3(CF2)nI (n?=?2, 3, 5, 7), (CF3)2CFI reacting with R-B(OH)2at room temperature under air in the presence of catalytic Cu powder provided exclusively the corresponding iodides (R-I), while the aerobic reactions of arylboronic acids with (CF3)2CFI at room temperature in the presence of Cu(OAc)2gave the perfluoroalkylation products (R-CF(CF3)2) in acceptable to moderate yields. The iodination reaction could be further promoted by hydroquinone, the addition of which improved the oxidation ability of (CF3)2CFI and provided the ipso-iodination products in high yields. The perfluoroalkylation was facilitated by the copper carboxylates since the addition of these salts into the reaction mixtures could successfully give rise to Ar-CF(CF3)2.