69682-13-9

Basic information

• Product Name: 4-(TERT-BUTYL)PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(TERT-BUTYL)PIPERIDINE HYDROCHLORIDE;4-(Tert-butyl)piperidineHCl;Piperidine, 4-(1,1-dimethylethyl)-, hydrochloride (1:1);4-(Tert-Butyl)Piperidine Hydrochloride(WX604384)
• CAS NO: 69682-13-9
• Molecular Formula: C₉H₁₉N*ClH
• Molecular Weight: 177.71
• Mol File: 69682-13-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 302 °C
• Boiling Point: 179.7 °C at 760 mmHg
• Flash Point: 54.9 °C
• Appearance: /
• Vapor Pressure: 0.931mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(TERT-BUTYL)PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYL)PIPERIDINE HYDROCHLORIDE(69682-13-9)
• EPA Substance Registry System: 4-(TERT-BUTYL)PIPERIDINE HYDROCHLORIDE(69682-13-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 69682-13-9(Hazardous Substances Data)

Usage

General Description

4-(tert-Butyl)piperidine hydrochloride is a chemical compound that consists of a piperidine ring with a tert-butyl group attached to the nitrogen atom and a hydrochloride salt. It is a white crystalline solid with a molecular formula of C11H24N.Cl. 4-(tert-Butyl)piperidine hydrochloride has applications in the pharmaceutical industry, as it can be used as a building block for the synthesis of various pharmaceutical drugs and as a reagent in organic chemistry. It is also used as a precursor for the preparation of other chemical compounds. 4-(tert-Butyl)piperidine hydrochloride is known for its low toxicity and relatively high stability, making it a useful and versatile chemical reagent.

InChI:InChI=1/C9H19N.ClH/c1-9(2,3)8-4-6-10-7-5-8;/h8,10H,4-7H2,1-3H3;1H

Upstream product

• 65520-02-7 4-(tert-butyl)pyridin-1-ium chloride 
• 3978-81-2 4-tert-butylpyridine 

Downstream Products

• 1448682-53-8 N-[(1S)-1-[4-[(4-tert-butylpiperidin-1-yl)methyl]phenyl]-2,2,2-trifluoroethyl]methanesulfonamide hydrochloride 
• 1448682-55-0 N-[(1S)-1-{4-[(4-tert-butylpiperidin-1-yl)methyl]phenyl}-2,2,2-trifluoroethyl]methanesulfonamide 
• 1882-42-4 4-tert-butylpiperidine 
• 787-50-8 N-benzoyl-4-tert-butylpiperidine 

Relevant articles and documents

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.

PHENYL METHANESULFONAMIDE DERIVATIVES USEFUL AS MGAT - 2 INHIBITORS

The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.