69716-05-8

Basic information

• Product Name: 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID
• Synonyms: 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID;(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID;2-(6-Methoxy-1-benzofuran-3-yl)acetic acid 97%;2-(6-Methoxy-1-benzofuran-3-yl)acetic acid ,97%;(6-Methoxybenzofuran-3-yl)aceticacid;(6-Methoxybenzo[b]furan-3-yl)acetic acid 97%;3-(Carboxymethyl)-6-methoxybenzo[b]furan;2-(6-methoxybenzofuran-3-yl)acetic acid
• CAS NO: 69716-05-8
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.19
• Mol File: 69716-05-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 123 °C
• Boiling Point: 369.3 °C at 760 mmHg
• Flash Point: 177.1 °C
• Appearance: /
• Density: 1.306 g/cm³
• Vapor Pressure: 4.17E-06mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: 2-8°C
• PKA: 4.12±0.30(Predicted)
• CAS DataBase Reference: 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID(69716-05-8)
• EPA Substance Registry System: 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID(69716-05-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 69716-05-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C11H10O4/c1-14-8-2-3-9-7(4-11(12)13)6-15-10(9)5-8/h2-3,5-6H,4H2,1H3,(H,12,13)

Upstream product

• 35231-44-8 4-(bromomethyl)-7-methoxycoumarin 
• 69716-04-7 2-(6-hydroxy-1-benzofuran-3-yl)acetic acid 
• 39581-48-1 methyl 2-(6-methoxy-1-benzofuran-3-yl)acetate 
• 726174-52-3 (6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester 
• 150-19-6 O-methylresorcine 
• 41295-55-0 4-(chloromethyl)-7-methoxy-2H-chromen-2-one 

Downstream Products

• 1609194-88-8 C₁₁H₁₂O₄ 
• 93198-72-2 (6-methoxy-2,3-dihydro-1-benzofuran-3-yl)acetic acid 

Relevant articles and documents

TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND

Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Synthesis and preliminary evaluation of benzofuran-oxadiazole conjugates as potential antitubercular agents

In the present study, a series of benzofuran-oxadiazole conjugates 7(a-o) was designed, synthesized and characterized through IR,1H NMR,13C NMR and mass spectral data. All the compounds were screened for preliminary antitubercular activity against Mycobacterium phlei and Mycobacterium tuberculosis H37RV. Among all the target compounds, the compound possessing chlorine (7k, MIC 1.56 μg/mL) and bromine (7m, MIC 1.56 μg/mL) on 6th position of benzofuran showed highest activity against Mycobacterium phlei. Whereas, bromine on either 5th position (7l, MIC 3.125 μg/mL) or 6th position (7m MIC 3.125 μg/mL) on benzofuran exhibited highest activity for Mycobacterium tuberculosis (H37 RV).

Efficient and Convenient Method for Synthesis of Benzofuran-3-acetic Acids and Naphthafuran-acetic Acids

Herein, we report an efficient and convenient method for synthesis of benzofuran-3-acetic acids and naphthafuran-acetic acids 5a-p by the reaction of substituted-4-bromomethylcoumarins with aqueous sodium hydroxide at refluxing temperature. The obtained products are characterized by infrared, 1H NMR, 13C NMR, and mass spectral data. Structures 5a and 5e are confirmed by their single x-ray diffraction studies. The advantages of this method are good yields, easy workup, and no chromatographic purifications.