6973-77-9

Basic information

• Product Name: N-(1-NAPHTHYL)MALEAMIC ACID
• Synonyms: N-(ALPHA-NAPHTHYL)MALEAMIC ACID;N-(1-NAPHTHYL)MALEAMIC ACID;Nsc24013;ASISCHEM U50591;3-(NAPHTHALEN-1-YLCARBAMOYL)-ACRYLIC ACID;AKOS AUF0575;OTAVA-BB BB7713090006
• CAS NO: 6973-77-9
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.24
• Mol File: 6973-77-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 533.9 °C at 760 mmHg
• Flash Point: 276.7 °C
• Appearance: /
• Density: 1.356 g/cm³
• Vapor Pressure: 3.15E-12mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: N-(1-NAPHTHYL)MALEAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-NAPHTHYL)MALEAMIC ACID(6973-77-9)
• EPA Substance Registry System: N-(1-NAPHTHYL)MALEAMIC ACID(6973-77-9)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 6973-77-9(Hazardous Substances Data)

Usage

Description

N-(1-NAPHTHYL)MALEAMIC ACID is a chemical compound with the molecular formula C14H11NO3. It is a derivative of maleic acid and is comprised of a maleic acid core with a 1-naphthyl substituent. This white to off-white solid is sparingly soluble in water but more soluble in organic solvents. It has been studied for its potential therapeutic properties, including its anti-tumor and anti-inflammatory effects, and is commonly used as a synthetic intermediate in the production of various pharmaceuticals, agrochemicals, and dyes.

Uses

Used in Pharmaceutical Industry:
N-(1-NAPHTHYL)MALEAMIC ACID is used as a synthetic intermediate for the development of various pharmaceuticals due to its potential therapeutic properties.
Used in Agrochemical Industry:
N-(1-NAPHTHYL)MALEAMIC ACID is used as a synthetic intermediate in the production of agrochemicals, contributing to the development of effective crop protection agents.
Used in Dye Industry:
N-(1-NAPHTHYL)MALEAMIC ACID is used as a synthetic intermediate for the creation of dyes, providing a range of color options for various applications.
Used in Therapeutic Applications:
N-(1-NAPHTHYL)MALEAMIC ACID is used as a potential therapeutic agent for its anti-tumor and anti-inflammatory effects, indicating its potential use in treating various health conditions.

InChI:InChI=1/C14H11NO3/c16-13(8-9-14(17)18)15-12-7-3-5-10-4-1-2-6-11(10)12/h1-9H,(H,15,16)(H,17,18)/b9-8-

Upstream product

• 108-31-6 maleic anhydride 
• 134-32-7 1-amino-naphthalene 

Relevant articles and documents

The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes

The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acid (4) derivatives containing structural characteristics that can be used for the synthesis of several active molecules, is presented. Some of the butenoic acid derivatives (4a, 4c, 4e, 4i, 4j, 4k) are

Synthesis and evaluation of hexahydropyrrolo[3,4-d]isoxazole-4,6-diones as anti-stress agents

A series of 2,3-diphenyl-5-(naphthalen-1-yl)-4H-2,3,3a,5,6,6a- hexahydropyrrolo[3,4-d]isoxazole-4,6-dione derivatives were synthesized via 1,3-dipolar cycloaddition of azomethine N-oxides with N-(α-naphthyl) maleimide. The pyrrolo-isoxazole derivatives were assigned cis- and trans- configurations (3-A and 3-B) with respect to proton C3-H on azomethinic carbon on the basis of their 1H NMR. The reaction proceeds through cis- endo addition rule indicating the predominance of cis isomer. The cis- and trans- isomers of a prototype compound 3a i.e., compound 3a-A and compound 3a-B were evaluated for anti-stress activity in immobilization-induced acute stress. Compound 3a-A (5 and 10 mg/kg) and compound 3a-B (10 mg/kg) attenuated immobilization stress-induced behavioral alterations in Swiss albino mice suggesting that pyrrolo-isoxazole may serve as lead molecule for the development of anti-stress agents.

Synthesis and characterization of new compounds containing 1,4-dithiintetracarboxydiimide units

New compounds containing 1,4-dithiintetracarboxydiimide units were synthesized by the disubstitution reaction of N-substituted 2,3- dichloromaleimide with sodium sulflde nonahydrate or thiourea. IR, UV-vis and 1H-NMR spectroscopy, as well as elemental analysis, confirmed their structures. Thermal conversion of 1,4-dithiine ring to thiophene was monitored by differential calorimetry (DSC) and thermogravimetric (TGA) measurements.