698-20-4Relevant articles and documents
MONOACYLGLYCEROL LIPASE MODULATORS
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Page/Page column 55; 122-123, (2021/08/20)
3.1.0 and 4.1.0 Azabicycle compounds of Formula (I), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, su
Cyclopropanation using flow-generated diazo compounds
Roda, Nuria M.,Tran, Duc N.,Battilocchio, Claudio,Labes, Ricardo,Ingham, Richard J.,Hawkins, Joel M.,Ley, Steven V.
supporting information, p. 2550 - 2554 (2015/11/17)
We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate f
Advantageous Syntheses of Diazo Compounds by Oxidation of Hydrazones with Lead Tetraacetate in Basic Environments
Holton, Terrence L.,Shechter, Harold
, p. 4725 - 4729 (2007/10/02)
Varied sensitive diazo compounds 3 are produced efficiently and safely in 3-6 g quantities by oxidation (eq 1) of hydrazones 1 at -78 deg C with lead tetraacetate (2) in triethylamine/chloroform, N-methylmorpholine/dimethylformamide, tetramethylguanidine (8)/dimethylformamide, and tetramethylguanidine/methylene chloride, respectively, upon use of appropriate workup and handling techniques.New and improved nonhazardous procedures have been developed for preparing and handling hydrazones 1 from aldehydes and ketones in reactions with excess hydrazine.