69805-82-9

Basic information

• Product Name: benzylcarbamic acid isobutyl ester
• Synonyms: benzylcarbamic acid isobutyl ester
• CAS NO: 69805-82-9
• Molecular Weight: 207.272
• Mol File: 69805-82-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: benzylcarbamic acid isobutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzylcarbamic acid isobutyl ester(69805-82-9)
• EPA Substance Registry System: benzylcarbamic acid isobutyl ester(69805-82-9)

Safety Data

• Hazardous Substances Data: 69805-82-9(Hazardous Substances Data)

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 100-46-9 benzylamine 
• 86123-95-7 (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid 
• 39896-97-4 benzyl-carbamic acid benzyl ester 
• 3173-56-6 benzyl isothiocyanate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 543-27-1 isobutyl chloroformate 
• 104272-90-4 isobutyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate 
• 104272-87-9 2-isobutoxycarbonyloxy-3,6-diisopropylpyrazine 
• 69805-76-1 4-(Isobutoxycarbonyloxy)-3-oxo-2,5-diphenyl-2,3-dihydrothiophen-1,1-dioxid 

Relevant articles and documents

Improved Synthesis and Impurity Identification of (R)-Lacosamide

An improved synthesis of Lacosamide 1 with high purity has been developed. Critical parameters of each step were identified as well as the impurities generated. Moreover, a creative method to improve chiral purity and stability of the key intermediate (R)-2-amino-N-benzyl-3-methoxypropionamide 10 by forming salt with an achiral acid (phosphoric acid) was discovered to ensure the chiral purity of (R)-Lacosamide. Phosphoric acid was further developed for the deprotection of the Boc group.

Effect of successive increase in alcohol chains on reaction with isocyanates and isothiocyanates

The reaction of isocyanates and isothiocyanates with long-chain alcohols, e.g. n-hexanol, n-heptanol and n-octanol, exclusively gave N-aryl-O-alkyl carbamates, while N-aryl-O-alkyl carbamates were formed along with symmetrical 1,3-disubstituted ureas and thioureas when the same reactions were carried out with small-chain alcohols at room temperature without using any solvent.

A practical synthesis of carbamates using an 'in-situ' generated polymer-supported chloroformate

A versatile method for the synthesis of carbamates from an 'in-situ' generated polymer-supported chloroformate resin is presented. BTC (bis-trichloromethyl carbonate) is used as phosgene equivalent to afford a supported chloroformate, which, by sequential 'one-pot' reaction with a variety of alcohols and amines, furnishes the corresponding carbamates in high yields and purities. A versatile method for the synthesis of carbamates from an 'in-situ' generated polymer-supported chloroformate resin is presented. BTC (bis-trichloromethyl carbonate) is used as phosgene equivalent to afford a supported chloroformate, which, by sequential 'one-pot' reaction with a variety of alcohols and amines, furnishes the corresponding carbamates in high yields and purities.