698348-05-9Relevant articles and documents
Synthesis of new 3-(1-ethylsulfanyl-2-perfluoroalkyl)-5-hydroxy-5-methyl (or 5-phenyl)-1,5-dihydro-pyrrol-2-ones Starting from γ-Keto thioesters and amines
Bouillon, Jean-Philippe,Tinant, Bernard,Nuzillard, Jean-Marc,Portella, Charles
, p. 711 - 721 (2004)
γ-Keto thioesters were easily transformed into α,β- unsaturated lactams using a two-step process (via furans) or by a one-pot reaction. This methodology is general and efficient leading to a varied substitution pattern. The structures of all new heterocycles were assigned using 2D NMR experiments, computer-assisted elucidation, and X-ray diffraction analyses.