698378-91-5

Basic information

• Product Name: alpha,alpha-Difluoro-2-furanacetic acid ethyl ester
• Synonyms: alpha,alpha-Difluoro-2-furanacetic acid ethyl ester;ethyl 2,2-difluoro-2-(2-furyl)acetate
• CAS NO: 698378-91-5
• Molecular Formula: C8H8F2O3
• Molecular Weight: 190
• Mol File: 698378-91-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 219℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.240
• CAS DataBase Reference: alpha,alpha-Difluoro-2-furanacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: alpha,alpha-Difluoro-2-furanacetic acid ethyl ester(698378-91-5)
• EPA Substance Registry System: alpha,alpha-Difluoro-2-furanacetic acid ethyl ester(698378-91-5)

Safety Data

• Hazardous Substances Data: 698378-91-5(Hazardous Substances Data)

Usage

General Description

Alpha,alpha-Difluoro-2-furanacetic acid ethyl ester is a chemical compound with the molecular formula C7H6F2O3. It is an ethyl ester derivative of difluorofuranacetic acid, which is a fluorinated compound. This chemical is used for its unique properties in various applications, including as a building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used in the synthesis of organic compounds and as a reagent in chemical reactions. alpha,alpha-Difluoro-2-furanacetic acid ethyl ester is characterized by its fluorine substitutions on the furan ring, which give it distinctive reactivity and physical properties.

Upstream product

• 110-00-9 furan 
• 667-27-6 Ethyl bromodifluoroacetate 
• 698378-63-1 ethyl α,α-difluoro-α-(phenylseleno)acetate 

Relevant articles and documents

Copper-Catalyzed C?H Difluoroalkylation of Coumarins with Fluoroalkyl Bromides

An efficient method for the copper-catalyzed selective C?H difluoroalkylation of coumarins and with low cost and readily available ethyl bromodifluoroacetate and N-phenyl bromodifluoroacetamide has been reported. This reaction exhibits good functional group tolerance with respect to coumarins and difluoroalkylation reagents, and several redox-sensitive substrates have been successfully C?H difluoroalkylated in good to high yield. This design could further expand the scope to other heteroarenes, including furan, benzofuran, pyrrole, pyridinone, chromenone, indole, and quinolinone. A mechanism involving copper-catalyzed in-situ generation of fluoroalkyl radical is proposed.

Direct introduction of ethoxycarbonyldifluoromethyl-group to heteroarenes with ethyl bromodifluoroacetate via visible-light photocatalysis

A mild and versatile approach for the direct introduction of ethoxycarbonyldifluoromethyl-group to heteroarenes via visible-light photocatalysis has been developed. The new photoredox protocol has enabled the difluoromethylenation of heteroarenes containing a wide range of common functional groups under mild conditions. Copyright

Aromatic substitution with photochemically generated difluoromethyl radicals bearing electron-withdrawing group

Novel and facile aromatic and heteroaromatic substitutions with difluoromethyl radicals bearing electron-withdrawing group generated by the photo-initiated Se-CF2 bond cleavage of ethyl α,α- difluoro-α-(phenylseleno)acetate and diethyl α,α- difluoromethyl-α-(phenylseleno)phosphonate were successfully carried out to provide the corresponding α-aryl-α,α-difluoroacetates and a-aryl-α,α-difluoromethylphosphonates in good to moderate yields.