699-01-4

Basic information

• Product Name: 1-fluoro-4-(prop-1-en-1-yl)benzene
• Synonyms: 1-fluoro-4-(prop-1-en-1-yl)benzene
• CAS NO: 699-01-4
• Molecular Weight: 136.169
• Mol File: 699-01-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-fluoro-4-(prop-1-en-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-(prop-1-en-1-yl)benzene(699-01-4)
• EPA Substance Registry System: 1-fluoro-4-(prop-1-en-1-yl)benzene(699-01-4)

Safety Data

• Hazardous Substances Data: 699-01-4(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 18826-59-0 1-(4-fluorophenyl)-prop-1-yne 
• 1737-16-2 1-allyl-4-fluorobenzene 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 591-87-7 Allyl acetate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1194-02-1 4-fluorobenzonitrile 
• 701-47-3 1-(4-fluorophenyl)propanol 

Downstream Products

• 218621-14-8 4-(4-fluorophenyl)-3-methyl-1,2,5-oxadiazole 2-oxide 
• 456-22-4 4-Fluorobenzoic acid 
• 459-02-9 4-fluoroamphetamine 
• 7139-24-4 4-fluorophenylbutyric acid 
• 51791-26-5 3-(4-fluoro-phenyl)-propenal 
• 444308-32-1 rac-1-(4-fluorophenyl)-2-propanol 

Relevant articles and documents

Enantioselective Resolution Copolymerization of Racemic 2,3-Disubstituted cis-Epoxides with CO2 Mediated by Binuclear Cobalt(III) Catalyst?

Enantioselective resolution copolymerization of racemic internal epoxides with carbon dioxide (CO2) is a challenging issue because of their poor reactivity and complicated regio/stereoselectivity. Herein, we describe the first enantioselective

Synthesis of Substituted β-Functionalised Styrenes by Microwave-Assisted Olefin Cross-Metathesis and Scalable Synthesis of Apremilast

Preparation of diversely substituted β-functionalised styrenes by microwave-assisted olefin cross-metathesis (CM) is described. This method can be also employed in the synthesis of β-deuterated α,β-unsaturated sulfones from inexpensive allylbenzenes, though unprecedented one-pot isomerisation/deuteration/cross-metathesis sequence. One of such obtained CM products has been utilised in a new scalable synthesis of Apremilast (6), a potent and orally active phosphodiesterase 4 and tumour necrosis factor-α inhibitor. The same strategy was used in synthesis of an optical antipode of 6, ent-Apremilast.

Alkene functionalization for the stereospecific synthesis of substituted aziridines by visible-light photoredox catalysis

A novel strategy involving visible-light-induced functionalization of alkenes for the synthesis of substituted aziridines was developed. The readily prepared N-protected 1-aminopyridinium salts were used for the generation of N-centered radicals. This approach allowed the synthesis of aziridines bearing various functional groups with excellent diastereoselectivity under mild conditions. Moreover, this protocol was successfully applied to prepare structurally diverse nitrogen-containing frameworks.