699-99-0

Basic information

• Product Name: 4-Fluoro-1-indanone
• Synonyms: 2,3-Dihydro-4-fluoro-1H-inden-1-one, 2,3-Dihydro-4-fluoro-1-oxo-1H-indene;1H-Inden-1-one, 4-fluoro-2,3-dihydro-;4-FLUORO-INDAN-1-ONE;4-fluoro-2,3-dihydro-1-indenone;4-FLUORO-1-INDANONE;4-Fluoroindan-1-one 98%;4-Fluoroindan-1-one98%;4-Fluoro-1-indanone, GC 98%
• CAS NO: 699-99-0
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.15
• Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;C8-C12;C9;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Ketones;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;API intermediates
• Mol File: 699-99-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 72-76°C
• Boiling Point: 242.752 °C at 760 mmHg
• Flash Point: 86.173 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 0.0263mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in alcohol and chloroform
• CAS DataBase Reference: 4-Fluoro-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-1-indanone(699-99-0)
• EPA Substance Registry System: 4-Fluoro-1-indanone(699-99-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 699-99-0(Hazardous Substances Data)

Usage

Description

4-Fluoro-1-indanone is a white crystalline compound that serves as an important raw material and intermediate in various organic synthesis processes.

Uses

Used in Medicine:
4-Fluoro-1-indanone is used as a pharmaceutical intermediate for the development of various medications due to its unique chemical properties and reactivity.
Used in Organic Synthesis:
4-Fluoro-1-indanone is used as a key intermediate in the synthesis of complex organic molecules, contributing to the creation of new compounds with potential applications in various industries.
Used in Pharmaceuticals:
4-Fluoro-1-indanone is used as a crucial building block in the production of pharmaceuticals, playing a significant role in the development of new drugs and therapies.
Used in Agrochemicals:
4-Fluoro-1-indanone is used as a vital component in the formulation of agrochemicals, such as pesticides and herbicides, to improve their effectiveness and target specific pests.
Used in Dye Industry:
4-Fluoro-1-indanone is used as a raw material in the synthesis of dyes, contributing to the development of new colorants with improved properties and applications.

InChI:InChI=1/C9H7FO/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5H,1,4H2

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 451-69-4 2-fluorocinnamic acid 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 196862-01-8 1-chloro-3-fluoro-2-vinylbenzene 
• 52163-89-0 3-(2-fluorophenyl)propanoyl chloride 

Downstream Products

• 57526-99-5 3-Fluorindan 
• 156484-68-3 2-bromo-4-fluoro-1-indanone 
• 148960-34-3 1-fluoro-benzocyclopentyl-5-amine 
• 1286734-90-4 (R)-4-fluoroindane-1-ylamine hydrochloride 
• 872181-31-2 2-fluoro-6-(4-fluoroindan-1-yloxy)-benzonitrile 
• 52085-95-7 4-fluoro-indan-1-ol 

Relevant articles and documents

Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of α-alkylated ketones in high yield (86 %–95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of α-alkylated ketones.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DSM265) is in clinical development. We sought to identify compounds with higher potency against Plasmodium DHODH while showing greater selectivity toward animal DHODHs. Herein we describe a series of novel triazolopyrimidines wherein the p-SF5-aniline was replaced with substituted 1,2,3,4-tetrahydro-2-naphthyl or 2-indanyl amines. These compounds showed strong species selectivity, and several highly potent tetrahydro-2-naphthyl derivatives were identified. Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P. falciparum SCID mouse malaria model. These data suggest that tetrahydro-2-naphthyl derivatives have the potential to be efficacious for the treatment of malaria, but due to higher metabolic clearance than 1, they most likely would need to be part of a multidose regimen.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.