69963-21-9

Basic information

• Product Name: 1-Butanone, 4-chloro-1-(3-pyridinyl)-
• CAS NO: 69963-21-9
• Molecular Formula: C9H10ClNO
• Molecular Weight: 183.637
• Mol File: 69963-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 4-chloro-1-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 4-chloro-1-(3-pyridinyl)-(69963-21-9)
• EPA Substance Registry System: 1-Butanone, 4-chloro-1-(3-pyridinyl)-(69963-21-9)

Safety Data

• Hazardous Substances Data: 69963-21-9(Hazardous Substances Data)

Usage

General Description

1-Butanone, 4-chloro-1-(3-pyridinyl)-, also known as 4-chloro-1-(3-pyridinyl)butan-1-one, is a chemical compound with the formula C9H9ClNO. It is a colorless liquid with a slightly sweet odor and is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. This chemical is also used in the manufacturing of different types of polymers and resins.

Upstream product

• 96-48-0 4-butanolide 
• 93-60-7 methyl 3-pyridinecarboxylate 

Downstream Products

• 40678-93-1 3-[2-(3-chloro-propyl)-[1,3]dioxolan-2-yl]-pyridine 
• 494-97-3 nornicotine 
• 71278-11-0 4-amino-1-(pyridin-3-yl)-1-butanone 
• 54-11-5 nicotin 
• 40678-94-2 1-phenyl-4-[3-(2-pyridin-3-yl-[1,3]dioxolan-2-yl)-propyl]-piperazine 

Relevant articles and documents

Method for synthesizing chiral nicotine from butyrolactone

The invention discloses a method for synthesizing chiral nicotine from butyrolactone. The fumarates and γ - butyrolactone are condensed under the action of a basic catalyst to yield 4 - chloro -1 - (3 - pyridine) -1 -butanone by reaction with hydrochloric acid and reacted with a chlorination reagent to produce (- B -) S (-4 -1 -dichlorobutyl) pyridine which is reacted with an amine reagent under basic conditions to give (-3 -) -1 -methyl nicotine and (S)-3 - nicotinic acetylbutanolamines obtained by the reaction with the aminating reagent under an alkaline condition to produce a chiral hydroxy S S group - (1) S- methylnicotine or a (4 -) S nicotinic acid. The application can determine whether a methylation reaction is needed according to the type of amination reagent. The yield of (S)- nicotine was high.