700-02-7Relevant articles and documents
Synthesis of (+)-agelasine C. A structural revision
Marcos,García,Sexmero,Basabe,Díez,Urones
, p. 11672 - 11678 (2005)
An efficient synthesis of (+)-agelasine C has been achieved from ent-halimic acid. The structure and absolute configuration of the natural product (-)-agelasine C was established and a structure for epi-agelasine C, is proposed.
Synthesis and biological activities of C-2, N-9 substituted 6- benzylaminopurine derivatives as cyclin-dependent kinase inhibitor
Oh, Chang-Hyun,Lee, Su-Chul,Lee, Ki-Soo,Woo, Eun-Rhan,Hong, Chang Yong,Yang, Boem-Seok,Baek, Dae Jin,Cho, Jung-Hyuck
, p. 187 - 190 (2007/10/03)
In this study, C-2, N-9 substituted 6-benzylaminopurine derivatives were synthesized and their inhibitory effects on cyclin-dependent kinase (CDK2) were evaluated. The effect of substituents at the C-2 and N-9 positions of substituted purine was investigated. Among the compounds tested, compound 7b- iii (6-benzylamino-2-thiomorpholinyl-9-isopropylpurine) was the most active inhibitor (IC50 = 0.9 μM). Compound 7b-iii showed 10-fold higher activity compared to olomoucine and almost the same activity as roscovitine. Results from structure-activity relationship studies should allow the design of more potent and selective CDK inhibitors, which may provide an effective therapy for cancer or other CDK dependent diseases.