70018-11-0 Usage
Description
1-(chloromethyl)-3-methyl-2-nitrobenzene is a chemical compound with the molecular formula C8H8ClNO2, derived from benzene and featuring a nitro group, a methyl group, and a chloromethyl group. It is a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and dyes.
Uses
Used in Pharmaceutical Industry:
1-(chloromethyl)-3-methyl-2-nitrobenzene is used as a key intermediate for the synthesis of various pharmaceuticals due to its unique functional groups that can be further modified in chemical reactions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(chloromethyl)-3-methyl-2-nitrobenzene is used as a building block for the development of new agrochemicals, such as pesticides and herbicides, leveraging its reactive functional groups for structural modifications.
Used in Dye Industry:
1-(chloromethyl)-3-methyl-2-nitrobenzene is utilized as a starting material in the production of various dyes, taking advantage of its chemical structure to create a range of colored compounds.
Safety and Handling:
It is crucial to handle 1-(chloromethyl)-3-methyl-2-nitrobenzene with caution due to its toxicity and potential to cause irritation to the skin, eyes, and respiratory system. Proper storage and disposal methods are essential to prevent environmental contamination.
Check Digit Verification of cas no
The CAS Registry Mumber 70018-11-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,0,1 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70018-11:
(7*7)+(6*0)+(5*0)+(4*1)+(3*8)+(2*1)+(1*1)=80
80 % 10 = 0
So 70018-11-0 is a valid CAS Registry Number.
70018-11-0Relevant articles and documents
Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde
Kyan, Ryuji,Mase, Nobuyuki,Narumi, Tetsuo,Sato, Kohei
, p. 19031 - 19036 (2020/08/25)
Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer.
