700376-84-7Relevant articles and documents
Acceptor-Controlled Transfer Dehydration of Amides to Nitriles
Okabe, Hiroyuki,Naraoka, Asuka,Isogawa, Takahiro,Oishi, Shunsuke,Naka, Hiroshi
supporting information, p. 4767 - 4770 (2019/06/17)
Palladium-catalyzed dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired scheme exergonic, thereby driving the dehydration.
Peptide ligation by chemoselective aminonitrile coupling in water
Canavelli, Pierre,Islam, Saidul,Powner, Matthew W.
, p. 546 - 549 (2019/07/31)
Amide bond formation is one of the most important reactions in both chemistry and biology1–4, but there is currently no chemical method of achieving α-peptide ligation in water that tolerates all of the 20 proteinogenic amino acids at the pepti
