70052-55-0

Basic information

• Product Name: 2-Propyn-1-amine, 3-(trimethylsilyl)-
• Synonyms: 2-Propyn-1-amine, 3-(trimethylsilyl)-;(3-Aminoprop-1-yn-1-yl)trimethylsilane
• CAS NO: 70052-55-0
• Molecular Formula: C₆H₁₃NSi
• Molecular Weight: 127.25962
• Mol File: 70052-55-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propyn-1-amine, 3-(trimethylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-amine, 3-(trimethylsilyl)-(70052-55-0)
• EPA Substance Registry System: 2-Propyn-1-amine, 3-(trimethylsilyl)-(70052-55-0)

Safety Data

• Hazardous Substances Data: 70052-55-0(Hazardous Substances Data)

Usage

General Description

2-Propyn-1-amine, 3-(trimethylsilyl)- is a chemical compound with the molecular formula C6H13NSi. It is an aliphatic amine with a propynyl group and a trimethylsilyl substituent. 2-Propyn-1-amine, 3-(trimethylsilyl)- is commonly used in organic synthesis as a reagent for the introduction of an amino group into other molecules. It is also utilized in the development of pharmaceuticals and in the production of various functionalized organic compounds. Additionally, 2-Propyn-1-amine, 3-(trimethylsilyl)- has been studied for its potential use in the synthesis of heterocyclic compounds with biological activity.

Upstream product

• 1365478-22-3 (3-azidoprop-1-ynyl)trimethylsilane 
• 71321-17-0 methanesulfonic acid 3-trimethylsilyl-propyn-2-ynyl ester 
• 5272-36-6 3-trimethylsilyl-2-propyn-1-ol 
• 351029-12-4 N-[3'-(trimethylsilyl)prop-2'-ynyl]phthalimide 
• 91375-26-7 1-(N,N-bis(trimethylsilyl)amino)-3-trimethylsilylprop-2-yne 

Downstream Products

• 1365478-26-7 (1R,3R,4R,5S)-3-[2-O-benzoyl-3-O-((1S)-1-carboxy-2-cyclohexylethyl)-(β-D-galactopyranosyl)oxy]-4-[(α-L-fucopyranosyl)oxy]-5-methyl-N-[3-(trimethylsilyl)prop-2-yn-1-yl]cyclohexanecarboxamide 
• 333332-83-5 4-methyl-benzenesulfinic acid (3-trimethylsilanyl-prop-2-ynyl)-amide 
• 333332-93-7 4-Methyl-benzenesulfinic acid (S)-(2-methyl-allyl)-(3-trimethylsilanyl-prop-2-ynyl)-amide 

Relevant articles and documents

Nanomolar e-selectin antagonists with prolonged half-lives by a fragment-based approach

Selectins, a family of C-type lectins, play a key role in inflammatory diseases (e.g., asthma and arthritis). However, the only millimolar affinity of sialyl Lewisx (sLex), which is the common tetrasaccharide epitope of all physiological selectin ligands, has been a major obstacle to the development of selectin antagonists for therapeutic applications. In a fragment-based approach guided by NMR, ligands binding to a second site in close proximity to a sLex mimic were identified. A library of antagonists obtained by connecting the sLex mimic to the best second-site ligand via triazole linkers of different lengths was evaluated by surface plasmon resonance. Detailed analysis of the five most promising candidates revealed antagonists with KD values ranging from 30 to 89 nM. In contrast to carbohydrate-lectin complexes with typical half-lives (t1/2) in the range of one second or even less, these fragment-based selectin antagonists show t1/2 of several minutes. They exhibit a promising starting point for the development of novel anti-inflammatory drugs.

Design and photophysical properties of zinc(II) porphyrin-containing dendrons linked to a central artificial special pair

The click chemistry synthesis and photophysical properties, notably photo-induced energy and electron transfers between the central core and the peripheral chromophores of a series of artificial special pair-dendron systems (dendron=G1, G2, G3; Gx=zinc(II) tetra-meso-arylporphyrin-containing polyimides) built upon a central core of dimethylxanthenebis(metal(II) porphyrin) (metal=zinc, copper), are reported. The dendrons act as singlet and triplet energy acceptors or donors, depending on the dendrimeric systems. The presence of the paramagnetic d9 copper(II) in the dendrimers promotes singlet-triplet energy transfer from the zinc(II) tetra-meso-arylporphyrin to the bis(copper(II) porphyrin) unit and slow triplet-triplet energy transfer from the central bis(copper(II) porphyrin) fragment to the peripheral zinc(II) tetra-meso-arylporphyrin. If bis(zinc(II) porphyrin) is the central core, evidence for chain folding is observed; this is unambiguously demonstrated by the presence of triplet-triplet energy transfer in the heterobimetallic systems, a process that can only occur at short distances.

Acetylene derivatives

Novel compounds of the following general formula are useful pharmacologic agents and are useful as intermediates for the preparation of pharmacologically useful compounds. STR1 wherein R1 is a straight or branched lower alkyl group having from 1 to 4 carbon atoms, R2 is trialkylmethyl, phenyl, 1-adamantanyl or 2-furyl; R3 is methoxy or ethoxy; and acid addition salts thereof.