7006-52-2

Basic information

• Product Name: 3-CHLORO-N-METHYLANILINE
• Synonyms: N-(3-Chlorophenyl)-N-methylamine;N-METHYL-3-CHLOROANILINE;N1-METHYL-3-CHLOROANILINE;3-CHLORO-N-METHYLANILINE;3-Chloro-1-Methylaniline;N-Methyl-3-chlorobenzenamine;3-Chloro-N-methylaniline,97%;(3-chlorophenyl)methylamine(SALTDATA: FREE)
• CAS NO: 7006-52-2
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.6
• EINECS: -0
• Product Categories: Amines;C7;Nitrogen Compounds
• Mol File: 7006-52-2.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 243-244 °C(lit.)
• Flash Point: >230 °F
• Appearance: clear yellow to brown liquid
• Density: 1.156 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0513mmHg at 25°C
• Refractive Index: n20/D 1.5840(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.05±0.25(Predicted)
• BRN: 2802319
• CAS DataBase Reference: 3-CHLORO-N-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-METHYLANILINE(7006-52-2)
• EPA Substance Registry System: 3-CHLORO-N-METHYLANILINE(7006-52-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 7006-52-2(Hazardous Substances Data)

Usage

Description

3-CHLORO-N-METHYLANILINE, also known as N-Methyl-3-chloroaniline, is an organic compound that serves as a valuable intermediate in the synthesis of various pharmaceuticals and chemical products. It is characterized by the presence of a chlorine atom attached to a methylaniline group, which provides unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
3-CHLORO-N-METHYLANILINE is used as a starting material for the preparation of various pharmaceutical compounds, including:
1. 2N-(2-bromoethyl)-N-methyl-3-chloroaniline: 3-CHLORO-N-METHYLANILINE is synthesized using 3-CHLORO-N-METHYLANILINE as a precursor, and it may have potential applications in the development of new drugs or drug candidates.
2. 2-[2-(N-methyl-3-chloroanilino)ethyl]-1,3-isoindolinedione: 3-CHLORO-N-METHYLANILINE is also derived from 3-CHLORO-N-METHYLANILINE and can be utilized in the synthesis of pharmaceutical agents with specific therapeutic properties.
3. N1-(3-chlorophenyl)-N1-methyl-1,2-ethanediamine dihydrochloride: 3-CHLORO-N-METHYLANILINE, obtained from 3-CHLORO-N-METHYLANILINE, can be used in the development of novel therapeutic agents with potential applications in medicine.

Upstream product

• 139-71-9 m-chloroformanilide 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 72681-27-7 3'-Chlor-N-methyltoluanilid 
• 80179-78-8 methyl N-3-chloeophenyl-N-methylcarbamate 
• 108-37-2 1-bromo-3-chlorobenzene 
• 74-89-5 methylamine 
• 64-18-6 formic acid 
• 108-42-9 3-chloro-aniline 
• 121-73-3 3-Nitrochlorobenzene 
• 7519-65-5 N-(3-chlorobenzylidene)aniline 
• 77-78-1 dimethyl sulfate 
• 535-80-8 3-chlorobenzoate 
• 50625-49-5 m-Chlorobenzoyl azide 

Downstream Products

• 80179-72-2 ethyl N-3-chloeophenyl-N-methylcarbamate 
• 1201591-88-9 N-(3-chlorophenyl)-N-methyl-3-(4-(pyrrolidin-1-yl)piperidin-1-yl)-5-(trifluoromethyl)benzamide 
• 1353642-47-3 N₁-methyl-N₃-(4-methylpiperazin-1-yl)-benzene-1,3-diamine 
• 1353642-38-2 N₁-(diphenylmethylene)-N₃-methylbenzene-1,3-diamine 
• 1353642-46-2 N₁-sec-butyl-N₃-methylbenzene-1,3-diamine 
• 1353642-37-1 N₁-methyl-N₃-octylbenzene-1,3-diamine 
• 1353642-56-4 N₁-methyl-N₃-(3-(trifluoromethyl)phenyl)-benzene-1,3-diamine 
• 1353642-45-1 N₁-cyclohexyl-N₃-methylbenzene-1,3-diamine 
• 1353642-55-3 N₁-(3,5-dimethylphenyl)-N₃-methylbenzene-1,3-diamine 
• 41919-03-3 N₁-methyl-N₃-phenylbenzene-1,3-diamine 
• 14814-75-6 N,N'-dimethyl-1,3-phenylenediamine 
• 6848-13-1 3-chloro-N,N-dimethylaniline 

Relevant articles and documents

Synthesis of 4-functionalized indoles via benzyne cyclization of N-(2- lithioallyl)-2-fluoroanilines

Treatment of N-(2-bromoallyl)-N-methyl-2-fluoroaniline with tert- butyllithium affords 1,3-dimethyl-4-lithioindole, via intramolecular addition to a tethered benzyne intermediate. Further reaction with electrophiles leads to 4-functionalized 3-methylindol

Iodine-Promoted Metal-Free Cyclization and O/S Exchange of Acrylamides with Thiuram: One-Step Synthesis of Quinolino-2-thiones

A one-step cyclization and O/S exchange reaction of readily available acrylamides in the presence of iodine and thiuram has been developed. The reaction provides an efficient approach for the synthesis of highly important heterocycle quinolino-2-thiones with diverse substitution patterns.

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.