70060-12-7

Basic information

• Product Name: 5-FLUOROBENZO[B]THIOPHENE
• Synonyms: 5-FLUOROBENZO[B]THIOPHENE;5-fiuorobenzo[b]thiophene;5-fluoro-1-benzothiophene;5-Fluorobenzothiophene
• CAS NO: 70060-12-7
• Molecular Formula: C₈H₅FS
• Molecular Weight: 152.19
• Mol File: 70060-12-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 59-61 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.298±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-FLUOROBENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUOROBENZO[B]THIOPHENE(70060-12-7)
• EPA Substance Registry System: 5-FLUOROBENZO[B]THIOPHENE(70060-12-7)

Safety Data

• Hazardous Substances Data: 70060-12-7(Hazardous Substances Data)

Usage

General Description

5-FLUOROBENZO[B]THIOPHENE is a chemical compound with the molecular formula C8H5FS. It is a heterocyclic organic compound containing a benzene ring fused to a thiophene ring with a fluorine substituent at the fifth position. 5-FLUOROBENZO[B]THIOPHENE is used in the synthesis of pharmaceuticals and agrochemicals, and it has potential applications in material science and organic electronics. 5-FLUOROBENZO[B]THIOPHENE is also studied for its biological activity and potential pharmacological properties, making it a subject of interest in medicinal chemistry research. It is important to handle this compound with care, as it may pose health and environmental hazards if not properly managed.

Upstream product

• 154630-32-7 methyl 5-fluorobenzo[b]thiophene-2-carboxylate 
• 371-42-6 4-Fluorothiophenol 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 13771-69-2 ethyl 5-fluorobenzo[b]thiophene-2-carboxylate 
• 70060-13-8 5-fluorobenzo[b]thiophene-2-carboxylic acid 
• 874357-16-1 (4-fluorophenylthio)-acetaldehyde dimethyl acetal 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 153687-44-6 (2,2-diethoxyethyl)(4-fluorophenyl)sulfane 

Downstream Products

• 118575-04-5 O-Benzyl-N-[1-(5-fluoro-benzo[b]thiophen-2-yl)-ethyl]-hydroxylamine 
• 346592-33-4 4-(5-fluoro-benzo[b]thiophen-2-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 346592-35-6 4-(5-fluoro-benzo[b]thiophen-2-yl)-4-hydroxy-2-methyl-piperidine-1-carboxylic acid tert-butyl ester 
• 698366-78-8 (E)-3-(5-fluorobenzo[b]thiophen-2-yl)-2-propen-1-ol 
• 698366-58-4 ethyl (E)-3-(5-fluorobenzo[b]thiophen-2-yl)-2-propenoate 
• 698367-59-8 1-(5-fluorobenzo[b]thiophen-2-yl)-3-(1H-imidazol-4-yl)-propan-1-ol 
• 138993-21-2 3-bromo-5-fluorobenzo[b]thiophene 
• 40740-56-5 5-fluoro-1-benzothiophene-3-carbaldehyde 
• 154630-32-7 methyl 5-fluorobenzo[b]thiophene-2-carboxylate 
• 102246-37-7 5-fluoro-2-methylbenzo[b]thiophene 
• 187658-19-1 3-acetyl-5-fluorobenzo[b]thiophen 
• 344764-43-8 3-chloro-1-(5-fluorobenzo[b]thiophen-3-yl)propan-1-one 
• 732223-07-3 2-amino-5-fluorobenzothiophene 

Relevant articles and documents

Enantioselective hydroarylation or hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes

An efficient protocol for the asymmetric hydroarylation and hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes has been developed. The combination of a rhodium(I) precatalyst and a chiral diene ligand constitutes the catalytic system, which enables the facile synthesis of 2,3-dihydrobenzo[b]thiophene 1,1-dioxides in good yields with high enantioselectivities. The merging of this asymmetric hydroarylation with the downstream alkylations delivers 2,3-dihydrobenzo[b]thiophene 1,1-dioxides that contain two continuous quaternary stereocenters with high enantioselectivities in a diastereodivergent manner.

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).