70080-54-5

Basic information

• Product Name: Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate
• Synonyms: Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate
• CAS NO: 70080-54-5
• Molecular Weight: 194.187
• Mol File: 70080-54-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate(70080-54-5)
• EPA Substance Registry System: Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate(70080-54-5)

Safety Data

• Hazardous Substances Data: 70080-54-5(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate, also known as ethyl ferulate, is a chemical compound with a molecular formula C11H12O5. It is an ester derived from ferulic acid, which is found in various plant sources such as rice bran and coffee. Ethyl ferulate has antioxidant properties and is commonly used in the food and cosmetic industries as a natural preservative and UV protectant. It also has potential anti-inflammatory and anti-cancer properties, making it a subject of interest in the field of medicine and pharmaceuticals. Overall, ethyl 2-(4-hydroxyphenyl)-2-oxoacetate is a versatile compound with various applications in different industries.

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 108-95-2 phenol 
• 43189-38-4 (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 68758-68-9 p-hydroxymandelic acid ethyl ester 

Downstream Products

• 1100934-14-2 C₁₃H₁₆O₄ 
• 1276023-72-3 C₁₉H₂₃N₃O₃ 
• 1276023-70-1 (S)-ethyl 2-(2-(tert-butoxycarbonylamino)-2-(4-propoxyphenyl)ethoxy)acetate 
• 1276021-66-9 C₁₆H₂₅NO₄ 
• 914202-84-9 C₁₁H₁₇NO₂ 
• 500773-98-8 C₁₃H₁₉NO₃ 
• 1276021-72-7 C₁₃H₁₇NO₄ 
• 1276021-65-8 (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one 
• 1276021-71-6 C₂₆H₃₀N₄O₃ 
• 1276021-73-8 (S)-tert-butyl 2-hydroxy-1-(4-propoxyphenyl)ethylcarbamate 
• 1276023-71-2 (S)-5-(4-propoxyphenyl)morpholin-3-one 
• 1276021-70-5 (S)-1-(4-methoxybenzyl)-4-(4-propoxyphenyl)imidazolidin-2-one 
• 1208307-63-4 C₂₂H₁₈N₄O₃ 

Relevant articles and documents

Aryl ketone amide compound, preparation method and application thereof

The invention discloses an aryl ketoamide compound or a pharmaceutically acceptable salt thereof, a preparation method and application thereof, wherein the compound has a structure represented by a general formula I, and in the formula, substituent groups are defined in the specification and claims. According to the invention, the compound provided by the invention can simultaneously inhibit the activity of various kinases, especially KDR, and further cell level detection results find that the compound has a remarkable inhibition effect on VEGF-induced human umbilical vein endothelial cell HUVEC proliferation, and is a small-molecular VEGFR-2 inhibitor with good activity at the enzyme level and the cell level, so that the compound provided by the invention can be developed into a medicinefor preventing and/or treating tumors or cancers.

NOVEL INHIBITORS

The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

Inhibitors of lipoprotein(a) assembly

Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral dosing