7010-86-8

Basic information

• Product Name: 4-Methoxy-N-methylbenzenesulphonamide
• Synonyms: 4-Methoxy-N-methylbenzenesulphonamide;4-methoxy-N-methylbenzenesulfonamide;BenzenesulfonaMide,4-Methoxy-N-Methyl-;4-(N-Methylsulphamoyl)anisole
• CAS NO: 7010-86-8
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.24284
• Mol File: 7010-86-8.mol
• Article Data: 29

Chemical Properties

• Melting Point: 98-100
• Boiling Point: 324.4 °C at 760 mmHg
• Flash Point: 150 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 0.000246mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 4-Methoxy-N-methylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-N-methylbenzenesulphonamide(7010-86-8)
• EPA Substance Registry System: 4-Methoxy-N-methylbenzenesulphonamide(7010-86-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 7010-86-8(Hazardous Substances Data)

Usage

General Description

4-Methoxy-N-methylbenzenesulphonamide is a chemical compound with the molecular formula C8H11NO3S. It is derived from the sulphonamide class of compounds and contains a methoxy group attached to a benzene ring. This chemical is used in medicinal and pharmaceutical applications as a reagent and intermediate for the synthesis of various compounds. It has been studied for its potential use in the treatment of various medical conditions, including cancer and infectious diseases, due to its pharmacological properties. Additionally, it is also used in the chemical industry for the production of other organic compounds.

InChI:InChI=1/C8H11NO3S/c1-9-13(10,11)8-5-3-7(12-2)4-6-8/h3-6,9H,1-2H3

Upstream product

• 593-51-1 methylamine hydrochloride 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 1129-26-6 4-methoxybenzene sulfonamide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 6140-09-6 sodium 4-methoxy-benzenesulfonate 
• 67-56-1 methanol 
• 108-30-5 succinic acid anhydride 
• 74-88-4 methyl iodide 
• 210820-71-6 4-methoxy-benzenesulfonic acid-(methyl-nitroso-amide) 
• 100-61-8 N-methylaniline 
• 74-89-5 methylamine 
• 86674-09-1 C₈H₁₀N₂O₅S 

Downstream Products

• 210820-71-6 4-methoxy-benzenesulfonic acid-(methyl-nitroso-amide) 
• 53119-88-3 N-(2-Hydroxy-1-phenyl-ethyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 53119-86-1 [(4-Methoxy-benzenesulfonyl)-methyl-amino]-phenyl-acetic acid methyl ester 
• 53119-84-9 (4-Methoxy-phenyl)-[methyl-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 
• 52260-06-7 N-Methyl-N-vinyl-p-methoxybenzolsulfonamid 
• 929205-76-5 N-methyl-2-iodo-4-methoxy-benzenesulfonamide 
• 929205-79-8 2-(4-hydroxy-but-1-ynyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 929205-80-1 2-(5-hydroxy-pent-1-ynyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 206258-26-6 4-[methyl-(4-methoxy-benzenesulfonyl)-amino]-8-bromo-quinoline-3-carboxylic acid 
• 52260-11-4 4-Methoxy-N-methyl-N-(1-phenyl-vinyl)-benzenesulfonamide 
• 52260-08-9 N-[1-(4-Methoxy-phenyl)-vinyl]-4,N-dimethyl-benzenesulfonamide 
• 202751-64-2 N-[(2-iodophenyl)methyl]-N-methyl-4-methoxybenzenesulfonamide 
• 86674-09-1 C₈H₁₀N₂O₅S 

Relevant articles and documents

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Direct Introduction of Sulfonamide Groups into Quinoxalin-2(1H)-ones by Cu-Catalyzed C3-H Functionalization

Direct sulfonamidation of quinoxalin-2(1H)-one derivatives has been developed using a readily available Cu salt as the catalyst and inexpensive ammonium persulfate as the oxidant in moderate conditions. Owing to the feature of handy operation and good functional group tolerance, this method provides a convenient and efficient access to curative 3-sulfonamidated quinoxalin-2(1H)-one scaffolds.