70160-87-1

Basic information

• Product Name: N,N,2-trimethyl-1-phenylpropan-1-amine
• CAS NO: 70160-87-1
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.286
• Mol File: 70160-87-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 213.5°C at 760 mmHg
• Flash Point: 75.1°C
• Density: 0.901g/cm³
• Vapor Pressure: 0.164mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: N,N,2-trimethyl-1-phenylpropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,2-trimethyl-1-phenylpropan-1-amine(70160-87-1)
• EPA Substance Registry System: N,N,2-trimethyl-1-phenylpropan-1-amine(70160-87-1)

Safety Data

• Hazardous Substances Data: 70160-87-1(Hazardous Substances Data)

Upstream product

• 21678-37-5 N,N,2-trimethylpropionamide 
• 591-51-5 phenyllithium 
• 920-39-8 isopropylmagnesium bromide 
• 50-00-0 formaldehyd 
• 6668-27-5 2-methyl-1-phenyl-propylamine 
• 124-40-3 dimethyl amine 
• 611-70-1 phenyl isopropyl ketone 

Relevant articles and documents

The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides

The reactions of the silyllithium reagent with tertiary amides was discussed. The enediamines were easily isomerized from cis to trans, easily oxidized to dienediamines and were hydrolyzed to α-aminoketones. If the two equivalents of the silyllithium reagent were used, the product was an α-silylamine. The results show that each member of the homologous series of amides gives rise to a substantially different product.

A convenient synthesis of hindered amines and α-trifluoromethylamines from ketones

Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl4/NaCNBH3. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reductive amination.