701981-08-0

Basic information

• Product Name: 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-1-[(1-oxopropyl-3-hydroxy)amino]-D-glycero-D-ido-heptitol
• CAS NO: 701981-08-0
• Molecular Weight: 625.762
• Mol File: 701981-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-1-[(1-oxopropyl-3-hydroxy)amino]-D-glycero-D-ido-heptitol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-1-[(1-oxopropyl-3-hydroxy)amino]-D-glycero-D-ido-heptitol(701981-08-0)
• EPA Substance Registry System: 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-1-[(1-oxopropyl-3-hydroxy)amino]-D-glycero-D-ido-heptitol(701981-08-0)

Safety Data

• Hazardous Substances Data: 701981-08-0(Hazardous Substances Data)

Upstream product

• 71119-79-4 2,6-anhydro-3,4,5,7-tetra-O-benzyl-D-glycero-D-ido-heptononitrile 
• 103977-05-5 1-amino-2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-D-glycero-D-ido-heptitol 
• 503-66-2 3-hydroxypropionic acid 

Relevant articles and documents

Recognition properties of processing α-glucosidase I and α-glucosidase II

All four possible monodeoxy derivatives of p-nitrophenyl α-D-glucopyranoside (PNP Glc) and 1-amino-2,6-anhydro-1-deoxy-D-glycero-D- ido-heptitol derivatives were prepared and used as substrates and inhibitors of rat liver processing α-glucosidases. α-Glucosidase II hydrolyzed the 2-deoxy derivative of PNP Glc (1); the hydrolysis of 1 was more rapid than that of PNP Glc. These results indicate that the presence of a C-2 hydroxyl group is not essential for the action of α-glucosidase II. In contrast, PNP Glc and all of the deoxy derivatives of PNP Glc 1-4 inhibited α-glucosidase I. These results indicate that α-glucosidase I does not necessarily need all of the hydroxyl groups of the glycon moiety for binding to the enzyme. 2,6-Anhydro-1-benzamide-D-glycero-D-ido-heptitol (11), with a terminal phenyl group, inhibited α-glucosidase I and α-glucosidase II. Both α-glucosidase I and II showed the same aglycon specificities. When probes 5-12 were assayed for their ability to inhibit processing by α-glucosidases at the cellular level, no effects on glycoprotein processing were observed.