70199-60-9

Basic information

• Product Name: 4-ethoxymethyl-pyridine
• Synonyms: 4-ethoxymethyl-pyridine
• CAS NO: 70199-60-9
• Molecular Formula: C₇H₉NO
• Molecular Weight: 137
• Mol File: 70199-60-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethoxymethyl-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxymethyl-pyridine(70199-60-9)
• EPA Substance Registry System: 4-ethoxymethyl-pyridine(70199-60-9)

Safety Data

• Hazardous Substances Data: 70199-60-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 108-89-4 picoline 
• 586-95-8 pyridine-4-methanol 
• 1007-48-3 4-acetoxymethylpyridine 
• 74-88-4 methyl iodide 
• 872-85-5 pyridine-4-carbaldehyde 
• 124-41-4 sodium methylate 
• 1822-51-1 4-picolylchloride hydrochloride 

Downstream Products

• 108-89-4 picoline 
• 1227159-73-0 2-[4-(methoxymethyl)piperidin-1-yl]-4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxa-diazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine 

Relevant articles and documents

4-methoxymethylpyridine synthesis method

The invention relates to the field of organic chemistry, particularly to a 4-methoxymethylpyridine synthesis method, which comprises: carrying out a bromination reaction on 4-methylpyridine as a raw material to obtain 4-bromo-methylpyridine; carrying out a reaction on the 4-bromo-methylpyridine and trimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide; and dissolving the (4-pyridylmethyl)trimethyl ammonium bromide in methanol, adding sodium methoxide, and carrying out heating reflux for 1 h in the presence of nitrogen to obtain the 4-methoxymethylpyridine. According to the invention, by using the synthesis method, 4-methylpyridine is used as the raw material, and is subjected to the bromination reaction to obtain 4-bromo-methylpyridine, the 4-bromo-methylpyridine reacts withtrimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide, and finally the (4-pyridylmethyl)trimethyl ammonium bromide reacts with sodium methoxide to obtain the 4-methoxymethylpyridine; and the synthesis method is high in total yield, cheap in raw material price, short in reaction time, mild in condition and simple in process operation.

Synthesis method for 4-methoxy methylpyridine

The invention belongs to the field of organic chemistry and particularly relates to a synthesis method for 4-methoxy methylpyridine. The method comprises the following steps of adopting 4-methylpyridine as a raw material and obtaining 4-bromo-methylpyridine through bromination reaction; reacting the 4-bromo-methylpyridine with trimethylamine to obtain (4-pyridylmethyl) trimethyl ammonium bromide; and dissolving the (4-pyridylmethyl) trimethyl ammonium bromide into methanol, adding sodium methylate, carrying out heating reflux under nitrogen for an hour to obtain the 4-methoxy-methyl pyridine. After the synthesis method is adopted, the 4-methylpyridine is adopted as the raw material to obtain the 4-bromo-methylpyridine through the bromination reaction, and the 4-bromo-methylpyridine reacts with the trimethylamine to obtain (4-pyridylmethyl) trimethyl ammonium bromide, and the (4-pyridylmethyl) trimethyl ammonium bromide finally reacts with the sodium methylate to obtain the 4-methoxy methylpyridine. The synthesis method is high in total yield, low in raw material price, short in reaction time, mild in condition and simple in technological operation.

Synthesis of alkyl heteryl ethers from acetates under interphase catalysis conditions in a liquid/solid system

The reaction of acetates of heterocyclic alcohols with alkyl halides in the two-phase catalytic system of solid KOH/C6H6/18-crown-6 at room temperature leads selectively to the formation of the corresponding heterocyclic ethers in 32-93% yield. 1998 Plenum Publishing Corporation.