70232-59-6

Basic information

• Product Name: (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE
• Synonyms: (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE;5-BROMO-3-NITRO-2-N-METHYLAMINOPYRIDINE;5-bromo-N-methyl-3-nitro-2-Pyridinamine
• CAS NO: 70232-59-6
• Molecular Formula: C₆H₆BrN₃O₂
• Molecular Weight: 232.03474
• Mol File: 70232-59-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE(70232-59-6)
• EPA Substance Registry System: (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE(70232-59-6)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 70232-59-6(Hazardous Substances Data)

Usage

General Description

The chemical (5-Bromo-3-nitro-pyridin-2-yl)-methyl-amine is a compound with the molecular formula C6H6BrN3O2. It is a derivative of pyridine and contains a bromine atom and a nitro group. (5-BROMO-3-NITRO-PYRIDIN-2-YL)-METHYL-AMINE is likely to have potential applications in the pharmaceutical and chemical industries due to its unique structure and properties. It may be used as a building block for synthesizing new drugs or other organic compounds. Further research and investigation into the properties and applications of (5-Bromo-3-nitro-pyridin-2-yl)-methyl-amine are necessary to fully understand its potential impact and uses.

Upstream product

• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 74-89-5 methylamine 

Downstream Products

• 152684-20-3 N-methyl-3-nitro-5-phenylpyridin-2-amine 
• 92260-32-7 6-bromo-2,3-dimethyl-3H-imidazo[4,5-b]pyridine 
• 107351-86-0 N²-methyl-5-phenylpyridine-2,3-diamine 
• 1366129-98-7 N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-(methylamino)-3-pyridinyl}benzenesulfonyamide 
• 1366131-90-9 C₁₈H₂₄BN₃O₄S 
• 1366131-89-6 N-[5-bromo-2-(methylamino)-3-pyridinyl]benzenesulfonamide 
• 89415-54-3 5-bromo-N²-methylpyridine-2,3-diamine 

Relevant articles and documents

Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders

Selective inhibitors of the GluN2B subunit of N-methyl-d-aspartate receptors in the ionotropic glutamate receptor superfamily have been targeted for the treatment of mood disorders. We sought to identify structurally novel, brain penetrant, GluN2B-selective inhibitors suitable for evaluation in a clinical setting in patients with major depressive disorder. We identified a new class of negative allosteric modulators of GluN2B that contain a 1,3-dihydro-imidazo[4,5-b]pyridin-2-one core. This series of compounds had poor solubility properties and poor permeability, which was addressed utilizing two approaches. First, a series of structural modifications was conducted which included replacing hydrogen bond donor groups. Second, enabling formulation development was undertaken in which a stable nanosuspension was identified for lead compound 12. Compound 12 was found to have robust target engagement in rat with an ED70 of 1.4 mg/kg. The nanosuspension enabled sufficient margins in preclinical toleration studies to nominate 12 for progression into advanced good laboratory practice studies.

AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

INHIBITORS OF HIV REPLICATION

Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.