70275-61-5

Basic information

• Product Name: Cyclohexanecarboxylic acid, 3-phenylpropyl ester
• CAS NO: 70275-61-5
• Molecular Formula: C16H22O2
• Molecular Weight: 246.349
• Mol File: 70275-61-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 3-phenylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 3-phenylpropyl ester(70275-61-5)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 3-phenylpropyl ester(70275-61-5)

Safety Data

• Hazardous Substances Data: 70275-61-5(Hazardous Substances Data)

Upstream product

• 14629-60-8 trimethyl(3-phenylpropoxy)silane 
• 69435-89-8 trimethylsilyl cyclohexanecarboxylate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 122-97-4 3-Phenyl-1-propanol 
• 110-82-7 cyclohexane 
• 201230-82-2 carbon monoxide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 4136-95-2 2,4,6-trichlorobenzoyl chloride 
• 204579-11-3 C₁₄H₁₃Cl₃O₃ 
• 434935-69-0 2-methyl-6-nitrobenzoic anhydride 
• 69404-95-1 tert-butyldimethyl(3-phenylpropoxy)silane 

Relevant articles and documents

Copper-Catalyzed Alkoxycarbonylation of Alkanes with Alcohols

Esters are important chemicals widely used in various areas, and alkoxycarbonylation represents one of the most powerful tools for their synthesis. In this communication, a new copper-catalyzed carbonylative procedure for the synthesis of aliphatic esters from cycloalkanes and alcohols was developed. Through direct activation of the C sp3 ?H bond of alkanes and with alcohols as the nucleophiles, the desired esters were prepared in moderate-to-good yields. Paraformaldehyde could also be applied for in situ alcohol generation by radical trapping, and moderate yields of the corresponding esters could be produced. Notably, this is the first report on copper-catalyzed alkoxycarbonylation of alkanes.

2,6-Dimethyl-4-nitrobenzoic anhydride (DMNBA): An effective coupling reagent for the synthesis of carboxylic esters and lactones

Various carboxylic esters are obtained at room temperature in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols using 2,6-dimethyl-4-nitrobenzoic anhydride with triethylamine by the promotion of 4-(dimethylamino)pyridine. The efficiency of the esterification is compared to those of other dehydrations using substituted benzoic anhydrides as coupling reagents. This method was successfully applied to the synthesis of threo-aleuritic acid lactone and the desired 17-membered ring compound was prepared in high yield at room temperature from the corresponding free trihydroxycarboxylic acid using 2,6-dimethyl-4-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine.

A new method for the synthesis of carboxylic esters and lactones with di-2-thienyl carbonate (2-DTC) by the promotion of DMAP and iodine

The esterification of carboxylic acids with alcohols by using di-2-thienyl carbonate (2-DTC) in the presence of a catalytic amount of 4-(dimethylamino) pyridine (DMAP) proceeded smoothly to afford the corresponding esters in good-to-high yields along with 2(5H)-thiophenone. This esterification was accelerated by the addition of an equimolar amount of iodine to afford the esters in higher yields within a shorter reaction time. Further, cyclization of ω-hydroxycarboxylic acids with an equimolar amount of 2-DTC in the presence of a catalytic amount of DMAP, followed by the addition of 1-4 equimolar amounts of iodine, afforded the corresponding lactones in good-to-high yields under mild conditions. This method was successfully employed in the synthesis of erythro-aleuritic acid lactone.