70277-02-0

Basic information

• Product Name: 3-Iodo-L-tyrosine methyl ester
• Synonyms: L-TYROSINE, 3-IODO-, METHYL ESTER;3-IODO-L-TYROSINE METHYL ESTER;3-INDO-L-TYROSINE METHYL ESTER;3-IODO-L-TYROSINE METHYL ESTER,98%MIN;(S)-Methyl 2-aMino-3-(4-hydroxy-3-iodophenyl)propanoate
• CAS NO: 70277-02-0
• Molecular Formula: C₁₀H₁₂INO₃
• Molecular Weight: 321.11
• Product Categories: Chiral Compound
• Mol File: 70277-02-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 347.6oC at 760 mmHg
• Flash Point: 164oC
• Appearance: /
• Density: 1.751g/cm3
• Vapor Pressure: 2.65E-05mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-Iodo-L-tyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-L-tyrosine methyl ester(70277-02-0)
• EPA Substance Registry System: 3-Iodo-L-tyrosine methyl ester(70277-02-0)

Safety Data

• Hazardous Substances Data: 70277-02-0(Hazardous Substances Data)

Usage

General Description

3-Iodo-L-tyrosine methyl ester is a chemical derivative of the amino acid tyrosine. 3-Iodo-L-tyrosine methyl ester is structurally modified by the introduction of an iodine atom and a methyl ester group. The iodine atom replaces one of the hydrogen atoms on the phenol group of tyrosine, making it a halogenated derivative. The methyl ester, on the other hand, is attached to the carboxyl group of the tyrosine which improves its ability to penetrate cellular membranes. 3-Iodo-L-tyrosine methyl ester is commonly used in medical and biochemical research, specifically in the area of thyroid studies, due to iodine's role in thyroid function. Its potential applications also extend into pharmacology where it functions as a precursor in the synthesis of sophisticated biologically active molecules.

InChI:InChI=1/C10H12INO3/c1-15-10(14)8(12)5-6-2-3-9(13)7(11)4-6/h2-4,8,13H,5,12H2,1H3/t8-/m0/s1

Upstream product

• 67-56-1 methanol 
• 70-78-0 3-Iodo-L-tyrosine 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 339220-96-1 (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-hydroxy-3-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester 
• 1364705-39-4 (S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 
• 1373311-90-0 N-tert-butoxycarbonyl-L-3-iodotyrosyl-L-3-iodotyrosine methyl ester 

Relevant articles and documents

Initial Analysis of the Arylomycin D Antibiotics

The arylomycins are a class of natural product antibiotics that inhibit bacterial type I signal peptidase and are under development as therapeutics. Four classes of arylomycins are known, arylomycins A-D. Previously, we reported the synthesis and analysis of representatives of the A, B, and C classes and showed that their spectrum of activity has the potential to be much broader than originally assumed. Along with a comparison of the mechanism of acquired and innate resistance, this led us to suggest that the arylomycins are latent antibiotics, antibiotics that once possessed broad-spectrum activity, but which upon examination today, have only narrow spectrum activity due to prior selection for resistance in the course of the competition with other microorganisms that drove their evolution in the first place. Interestingly, actinocarbasin, the only identified member of the arylomycin D class, has been reported to have activity against MRSA. To confirm and understand this activity, several actinocarbasin derivatives were synthesized. We demonstrate that the previously reported structure of actinocarbasin is incorrect, identify what is likely the correct scaffold, confirm that scaffold has activity against MRSA, and determine the origin of this activity.

Tyrosine-derived stimuli responsive, fluorescent amino acids

A series of fluorescent unnatural amino acids (UAAs) bearing stilbene and meta-phenylenevinylene (m-PPV) backbone have been synthesized and their optical properties were studied. These novel UAAs were derived from protected diiodo-l-tyrosine using palladi

Syntheses of F-18 labeled fluoroalkyltyrosine derivatives and their biological evaluation in rat bearing 9L tumor

We hereby report the synthesis of four fluorine-18 labeled tyrosine derivatives, 3-(2-[18F]fluoroethyl)tyrosine ([18F]1, [18F]ortho-FET), 3-(3-[18F]fluoropropyl)tyrosine ([18F]2, [18F]ortho