70415-59-7

Basic information

• Product Name: N-nitrosomethyl-(3-hydroxypropyl)amine
• Synonyms: N-nitrosomethyl-(3-hydroxypropyl)amine;3-(Methylnitrosoamino)-1-propanol
• CAS NO: 70415-59-7
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 118.16
• Mol File: 70415-59-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 220.67°C (rough estimate)
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.2188 (rough estimate)
• Vapor Pressure: 0.000262mmHg at 25°C
• Refractive Index: 1.4386 (estimate)
• Storage Temp.: Amber Vial, Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: N-nitrosomethyl-(3-hydroxypropyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-nitrosomethyl-(3-hydroxypropyl)amine(70415-59-7)
• EPA Substance Registry System: N-nitrosomethyl-(3-hydroxypropyl)amine(70415-59-7)

Safety Data

• Hazardous Substances Data: 70415-59-7(Hazardous Substances Data)

Usage

Description

N-nitrosomethyl-(3-hydroxypropyl)amine, also known as 3-(Methylnitrosoamino)-1-propanol, is a chemical compound that serves as an intermediate in the synthesis of 3-(Methylnitrosamine)propionaldehyde (MNPA). MNPA is a potent carcinogen that was first detected in the saliva of betel quid chewers and is known for its higher cytotoxicity compared to other nitrosamines such as Nitrosoguvacine (NGC), Nitrosoguvacoline (NG), and 3-(Methylnitrosamino)propionitrile (MNPN).

Uses

Used in Research and Development:
N-nitrosomethyl-(3-hydroxypropyl)amine is used as a research compound for studying the properties and effects of MNPA and other related nitrosamines. Its role as an intermediate in the synthesis of MNPA makes it valuable for understanding the mechanisms of carcinogenesis and cytotoxicity associated with these compounds.
Used in Toxicology Studies:
Due to its higher cytotoxicity compared to other nitrosamines, N-nitrosomethyl-(3-hydroxypropyl)amine is utilized in toxicology studies to investigate the potential health risks and effects of exposure to MNPA and similar compounds. This helps in developing strategies for risk assessment, prevention, and mitigation of the harmful effects of these carcinogens.
Used in Regulatory Compliance and Monitoring:
N-nitrosomethyl-(3-hydroxypropyl)amine is also used in regulatory compliance and monitoring efforts to ensure the safety of consumer products and environmental conditions. By understanding the presence and effects of MNPA and related compounds, regulatory agencies can establish guidelines and standards to protect public health.

Safety Profile

Questionable carcinogen withexperimental carcinogenic data. When heated todecomposition it emits toxic vapors of NOx.

InChI:InChI=1/C4H10N2O2/c1-6(5-8)3-2-4-7/h7H,2-4H2,1H3

Upstream product

• 42055-15-2 N-methyl-3-hydroxypropylamine 

Downstream Products

• 66398-65-0 N-Methyl-N-nitroso-3-(tosyloxy)propylamin 

Relevant articles and documents

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