70424-54-3Relevant articles and documents
Biologically active quassinoids : synthetic methodology for the conversion of chaparrin into glaucarubolone esters and quassinoid analogs1 1 For previous paper in this series see: C. Moretti, S. Bhatnagar, J.C. Beloeil and J. Polonsky, J. Nat. Prods., 49, 440 (1986)
Bhatnagar, Subodh C.,Caruso, Andrew J.,Polonsky, Judith,Rodriguez, Berta Soto
, p. 3471 - 3480 (1987)
Biologically inactive but easily available chaparrin 2a has been converted into potent antileukemic C-15 esters of glaucarubolone 2b and quassinoid analogs in which the C-15 ester side chain has been replaced by an alkyl or alkenyl group.The synthetic methodology developed has been applied to the preparation of C-15 ester derivatives 15, 16, 17 and quassinoid analogs 12, 13 and 14.