7043-09-6

Basic information

• Product Name: 4,6-dichloro-2-cyclopropylpyrimidine
• Synonyms: 4,6-dichloro-2-cyclopropylpyrimidine
• CAS NO: 7043-09-6
• Molecular Formula: C7H6Cl2N2
• Molecular Weight: 189
• Mol File: 7043-09-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105-107 °C
• Boiling Point: 268.5 °C at 760 mmHg
• Flash Point: 142.1 °C
• Appearance: /
• Density: 1.479 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.63±0.30(Predicted)
• CAS DataBase Reference: 4,6-dichloro-2-cyclopropylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-2-cyclopropylpyrimidine(7043-09-6)
• EPA Substance Registry System: 4,6-dichloro-2-cyclopropylpyrimidine(7043-09-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7043-09-6(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-cyclopropylpyrimidine is a chemical compound with the formula C7H5Cl2N2. It is most recognized as an intermediate used in the synthesis of various pharmaceutical compounds, particularly antiviral drugs. This chemical belongs to the class of organic compounds known as pyrimidines and pyrimidine derivatives. They are characterized by a pyrimidine ring, which is a six-membered heterocyclic ring with two nitrogen atoms and four carbon atoms. More specifically, 4,6-Dichloro-2-cyclopropylpyrimidine has a cyclopropyl group attached at the 2-position of the pyrimidine ring and two chlorines at the 4 and 6 positions which make it very useful in the realm of organic synthesis.

Upstream product

• 7024-58-0 2-cyclopropyl-4,6-dihydroxy-pyrimidine 

Relevant articles and documents

PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS

The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

4-AMINO-PYRIMIDINE DERIVATIVES

4-Amino-pyrimidine derivatives of Formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.

CHEMICAL COMPOUNDS WITH DUAL ACTIVITY, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS

The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.