704888-93-7

Basic information

• Product Name: N-ethyloxy-4-methoxybenzenesulfonamide
• Synonyms: N-ethyloxy-4-methoxybenzenesulfonamide
• CAS NO: 704888-93-7
• Molecular Weight: 231.273
• Mol File: 704888-93-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-ethyloxy-4-methoxybenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyloxy-4-methoxybenzenesulfonamide(704888-93-7)
• EPA Substance Registry System: N-ethyloxy-4-methoxybenzenesulfonamide(704888-93-7)

Safety Data

• Hazardous Substances Data: 704888-93-7(Hazardous Substances Data)

Upstream product

• 3332-29-4 O-ethylhydroxylamine hydrochloride 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Downstream Products

• 704889-11-2 2-{ethyloxy[(4-methoxyphenyl)sulfonyl]amino}acetic acid O-(tert-butyldimethylsilyl)hydroxyamide 
• 704889-05-4 {ethyloxy[(4-methoxyphenyl)sulfonyl]amino}acetic acid 
• 704888-99-3 tert-butyl {ethyloxy[(4-methoxyphenyl)sulfonyl]amino}acetate 

Relevant articles and documents

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase a (MMP-2)

New N-arylsulfonyl-substituted alkoxyaminoaceto hydroxamic acid derivatives of types 8 and 10 designed as oxa-analogues of known sulfonamide-based MMPi of types 2 and 7 were synthesized and tested for their inhibitory activities on some matrix metalloproteinases. The combination of a biphenylsulfonamide group with oxyamino oxygen in the pharmacophoric central skeleton of sulfonamide-based MMPi obtained in the new sulfonamides 10 seems to be able to give selectivity for MMP-2 over MMP-1. The most potent derivative of this type, 10a, shows similar anti-invasive properties to the analogue reference drug CGS27023A, 2, in an in vitro model of invasion on matrigel, carried out on cellular lines of fibrosarcoma HT1080 (tumoural cells over-expressing MMP-2 and MMP-9).