704910-45-2

Basic information

• Product Name: Zinc, chloro-2-cyclohexen-1-yl-
• CAS NO: 704910-45-2
• Molecular Formula: C6H9ClZn
• Molecular Weight: 181.98
• Mol File: 704910-45-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Zinc, chloro-2-cyclohexen-1-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Zinc, chloro-2-cyclohexen-1-yl-(704910-45-2)
• EPA Substance Registry System: Zinc, chloro-2-cyclohexen-1-yl-(704910-45-2)

Safety Data

• Hazardous Substances Data: 704910-45-2(Hazardous Substances Data)

Upstream product

• 7646-85-7 zinc(II) chloride 
• 1165952-91-9 cyclohexa-1,3-diene 
• 2441-97-6 3-chloro-cyclohexene 
• 7440-66-6 zinc 
• 112520-99-7 tributyl(cyclohex-2-en-1-yl)stannane 

Downstream Products

• 1064062-07-2 (4S)-4-{(S)-[(S)-cyclohex-2-enyl](hydroxy)methyl}-4-{[(2-methoxyethoxy)methoxy]methyl}-3-(4-methoxybenzyl)oxazolidin-2-one 
• 1039750-76-9 (S)-2-methyl-propane-2-sulfinic acid [(S)-1-((S)-cyclohex-2-enyl)-1-phenylpropyl]amide 
• 1039750-75-8 (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-phenyl)-1-((S)-cyclohex-2-enyl)ethyl]amide 
• 1039750-74-7 (S)-2-methyl-propane-2-sulfinic acid [(S)-1-((S)-cyclohex-2-enyl)-1-phenylethyl]amide 
• 1039750-73-6 (S)-2-methyl-propane-2-sulfinic acid [(S)-((S)-cyclohex-2-enyl)-(furan-2-yl)methyl]amide 
• 1039750-72-5 (S)-2-methyl-propane-2-sulfinic acid [(R)-1-((S)-cyclohex-2-enyl)propyl]amide 
• 1039750-71-4 (S)-2-methyl-propane-2-sulfinic acid [(R)-cyclohexyl-((S)-cyclohex-2-enyl)methyl]amide 
• 1039750-70-3 (S)-2-methyl-propane-2-sulfinic acid [(S)-(4-fluoro-2-bromo-phenyl)-((S)-cyclohex-2-enyl)methyl]amide 
• 1039750-69-0 (S)-2-methyl-propane-2-sulfinic acid [(S)-(4-methoxy-phenyl)-((S)-cyclohex-2-enyl)methyl]amide 
• 1039750-68-9 (S)-2-methyl-propane-2-sulfinic acid [(S)-(4-methyl-phenyl)-((S)-cyclohex-2-enyl)methyl]amide 
• 1039750-67-8 (S)-2-methyl-propane-2-sulfinic acid [(S)-((S)-cyclohex-2-enyl)-(4-fluoro-phenyl)methyl]amide 
• 1039750-66-7 (S)-2-methyl-propane-2-sulfinic acid [(S)-(4-bromo-phenyl)-((S)-cyclohex-2-enyl)methyl]amide 
• 704910-39-4 (3R,3aS,7aR)-3-((S)-(S)-Cyclohex-2-enyl-hydroxy-methyl)-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester 

Relevant articles and documents

PROTEASOME INHIBITING ?-LACTAM PRODRUGS USEFUL FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS

The present invention relates generally to proteasome inhibiting β-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

ANALOGS OF SALINOSPORAMIDE A

Disclosed herein are analogs of Salinosporamide A, having the Formulae Ia - IVa as follows: [insert chemical formula here] Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzyme complex that destroys proteins the cell no longer needs. Without the proteasome, proteins would build up and clog cellular machinery. Fast-growing cancer cells make especially heavy use of the proteasome, so thwarting its action is a compelling drug strategy.