7051-15-2

Basic information

• Product Name: 2-Chloro-1,3-dimethoxy-benzene
• Synonyms: 2-Chloro-1,3-dimethoxy-benzene
• CAS NO: 7051-15-2
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.60886
• EINECS: 604-604-1
• Mol File: 7051-15-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 69-71 °C(Solv: hexane (110-54-3))
• Boiling Point: 233.72°C at 760 mmHg
• Flash Point: 89.215°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-1,3-dimethoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-1,3-dimethoxy-benzene(7051-15-2)
• EPA Substance Registry System: 2-Chloro-1,3-dimethoxy-benzene(7051-15-2)

Safety Data

• Hazardous Substances Data: 7051-15-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-1,3-dimethoxy-benzene, also known as 6-chloroguaiacol, is a chemical compound with the molecular formula C8H9ClO2. It is a chlorinated derivative of guaiacol, a natural organic compound found in wood smoke. 2-Chloro-1,3-dimethoxy-benzene is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also used in the production of dyes, perfumes, and flavorings. The compound is a clear, colorless liquid with a strong, aromatic odor and is considered to be hazardous if not handled properly. It is important to follow safety protocols and guidelines when working with 2-Chloro-1,3-dimethoxy-benzene.

InChI:InChI=1/C8H9ClO2/c1-10-6-4-3-5-7(11-2)8(6)9/h3-5H,1-2H3

Upstream product

• 6201-65-6 2-chlororesorcinol 
• 77-78-1 dimethyl sulfate 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 151-10-0 1,3-Dimethoxybenzene 
• 2785-97-9 (2,6-dimethoxyphenyl)lithium 
• 67-72-1 hexachloroethane 
• 109-72-8 n-butyllithium 
• 13444-90-1 Nitryl chloride 
• 16932-45-9 1-bromo-2,6-dimethoxybenzene 
• 74-88-4 methyl iodide 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 142599-76-6 bis(2,6-dimethoxyphenyl)dimethyltin 

Downstream Products

• 72482-14-5 3-chloro-2,4-dimethoxybenzaldehyde 
• 102312-34-5 1,3,5-trichloro-2,4-dimethoxy-benzene 
• 131157-38-5 Ethyl 2-(2,6-dimethoxyanilino)benzoate 
• 131157-28-3 N-(2,6-dimethoxyphenyl)aniline 
• 72482-19-0 [5,7-Dichloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester 
• 72482-24-7 ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate 
• 72498-56-7 ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>oxy>acetate 
• 72482-13-4 {[7-chloro-3-(2,5-difluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid 
• 72482-20-3 {[5,7-dichloro-3-(2-fluorophenyl)-1,2-benzisoxazole-6-yl]oxy}acetic acid 
• 72582-55-9 C₁₆H₁₂ClF₂NO₄ 

Relevant articles and documents

Derivatives of m-Guaiacol, Their Preparation and Their Uses

The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.

Halogenase-Inspired Oxidative Chlorination Using Flavin Photocatalysis

Chlorine gas or electropositive chlorine reagents are used to prepare chlorinated aromatic compounds, which are found in pharmaceuticals, agrochemicals, and polymers, and serve as synthetic precursors for metal-catalyzed cross-couplings. Nature chlorinates with chloride anions, FAD-dependent halogenases, and O2 as the oxidant. A photocatalytic oxidative chlorination is described based on the organic dye riboflavin tetraacetate mimicking the enzymatic process. The chemical process allows within the suitable arene redox potential window a broader substrate scope compared to the specific activation in the enzymatic binding pocket. Chlorination of arenes with chloride anions: The photochemical analogue of the enzymatic chlorination of Flavin-adenine dinucleotide (FAD)-dependent halogenases is possible in the presence of riboflavin, air, acetic acid, and blue light (see scheme; RFT=riboflavin tetraacetate).

Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis

Two unidentified chlorinated volatiles X and Y were detected in headspace extracts of the fungus Geniculosporium. Their mass spectra pointed to the structures of a chlorodimethoxybenzene for X and a dichlorodimethoxybenzene for Y. The mass spectra of some constitutional isomers for X and Y were included in our databases and proved to be very similar, thus preventing a full structural assignment. For unambiguous structure elucidation all possible constitutional isomers for X and Y were obtained by synthesis or from commercial suppliers. Comparison of mass spectra and GC retention times rigorously established the structures of the two chlorinated volatiles. Chlorinated volatiles are not very widespread, but brominated or even iodinated volatiles are even more rare. Surprisingly, headspace extracts from Streptomyces chartreusis contained methyl 2-iodobenzoate, a new natural product that adds to the small family of iodinated natural products.