70523-24-9 Usage
Description
2,4-Bis(benzyloxy)pyrimidine-5-boronic acid is an organic compound characterized by its pyrimidine core, which is substituted with two benzyloxy groups at the 2nd and 4th positions and a boronic acid group at the 5th position. This unique structure endows it with specific chemical properties and reactivity, making it a valuable intermediate in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
2,4-Bis(benzyloxy)pyrimidine-5-boronic acid is used as a key reactant in the design and synthesis of acyclic fleximer nucleoside analogues. These analogues are of significant interest in medicinal chemistry due to their potential as antiviral and anticancer agents. The boronic acid functionality in this compound allows for the formation of stable covalent bonds with biological targets, such as enzymes or receptors, thereby modulating their activity and contributing to the therapeutic effects of the resulting nucleoside analogues.
Check Digit Verification of cas no
The CAS Registry Mumber 70523-24-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,5,2 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 70523-24:
(7*7)+(6*0)+(5*5)+(4*2)+(3*3)+(2*2)+(1*4)=99
99 % 10 = 9
So 70523-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H17BN2O4/c22-19(23)16-11-20-18(25-13-15-9-5-2-6-10-15)21-17(16)24-12-14-7-3-1-4-8-14/h1-11,22-23H,12-13H2
70523-24-9Relevant articles and documents
Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki-Miyaura coupling and their 1,3-dipolar cycloaddition reactions with nitrones
Wójtowicz-Rajchel, Hanna,Koroniak, Henryk
scheme or table, p. 225 - 230 (2012/04/04)
A simple two-step synthesis of a new class of fluorinated isoxazolidinyl derivatives of pyrimidine is described. The reactions proceed via the Suzuki-Miyaura coupling followed by highly regioselective 1,3-dipolar cycloaddition with nitrones. Removal of th