705280-36-0

Basic information

• Product Name: 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one
• Synonyms: 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one
• CAS NO: 705280-36-0
• Molecular Weight: 305.163
• Mol File: 705280-36-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one(705280-36-0)
• EPA Substance Registry System: 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one(705280-36-0)

Safety Data

• Hazardous Substances Data: 705280-36-0(Hazardous Substances Data)

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 86-52-2 1-Chloromethylnaphthalene 

Downstream Products

• 1421365-85-6 C₂₄H₂₁ClN₂O₅ 
• 1421365-84-5 C₂₃H₁₉ClN₂O₄ 
• 1421365-83-4 C₂₃H₁₉ClN₂O₂ 
• 1421365-82-3 C₂₃H₁₉ClN₂O₃ 
• 1421365-81-2 C₂₂H₁₇ClN₂O₃ 
• 1421365-80-1 C₂₂H₁₇ClN₂O₂S 
• 1421365-79-8 C₂₃H₁₇ClN₂O₄ 
• 1421365-78-7 C₂₄H₂₁ClN₂O₃ 
• 1421365-77-6 C₂₂H₁₄ClF₃N₂O₃ 
• 1421365-76-5 C₂₃H₁₉ClN₂O₂ 
• 1421365-75-4 C₂₄H₂₁ClN₂O₃ 
• 1421365-74-3 CYM₅₀₇₇₅ 
• 1421365-73-2 C₂₂H₁₆ClFN₂O₃ 
• 1421365-72-1 C₂₂H₁₆ClFN₂O₃ 

Relevant articles and documents

SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists

In this Letter we report on the advances in our NPBWR1 antagonist program aimed at optimizing the 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule previously obtained from a high-throughput screening (HTS)-derived hit. Synthesis and structure-activity relationships (SAR) studies around the 3,5-dimethylphenyl and 4-methoxyphenyl regions resulted in the identification of a novel series of non-peptidic submicromolar NPBWR1 antagonists based on a 5-chloro-4-(4-alkoxyphenoxy)-2-(benzyl)pyridazin-3(2H)- one chemotype. Amongst them, 5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one 9h (CYM50769) inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance. Our medicinal chemistry study provides innovative non-peptidic selective NPBWR1 antagonists that may enable to clarify the biological role and therapeutic utility of the target receptor in the regulation of feeding behavior, pain, stress, and neuroendocrine function.