7056-32-8Relevant articles and documents
Potential antibacterial agents. Part III. Synthesis of 7-oxa-spiro [5, 9] pentadecane-1, 8, 13 trione: A novel macrocyclic lactone
Husain, Shaheen A.,Sarfaraz, Tahira B.,Murtaza, Najma,Sultana, Naheed
, p. 180 - 183 (2007/10/03)
In an attempt towards synthesis of intermediates (2a) 2-(1-cyanoethyl) cyclohexanone, (2b), 2-(1-nitroethyl) cyclohexanone reaction of morpholinomethyl cyclohexanone hydrochloride with CH3CN (or CH3NO2) was undetaken. Instead of the two intermediates namely 2a, 2b the known compound 3 1-(1-oxo-2-hydroxycyclohexyl)-2-(2-oxocyclohexyl)-ethane was obtained. Oxidation of this compound and its LAH reduction product 4 1-(1,2-dihydroxycyclohexyl) -2- (2- hydroxycyclohexyl) ethane with CrO3/Ac OH furnished a hitherto un-described compound 5, oxa-spiro [5,9] -pentadecane-1,8,13 trione. Its structure was established using spectroscopie techniques such as IR, HRIMS 1H-NMR, 13C-NMR etc. Antibacterial activities of the three synthesized compounds have been evaluated.