7057-48-9 Usage
Description
2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE, also known as Didanosine EP Impurity I, is a purine analog that is found as an impurity in Didanosine (D440950). It is used in the pharmaceutical industry as an antiviral agent and is classified as an anti-retroviral drug.
Uses
Used in Pharmaceutical Industry:
2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE is used as an impurity in Didanosine, which is an antiviral agent for the treatment of HIV in ART therapy. It plays a role in the development and formulation of anti-retroviral drugs.
Used in Antiviral Applications:
2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE is used as a component in the development of anti-retroviral drugs, specifically Didanosine, which is used in the treatment of HIV. It contributes to the overall effectiveness of the drug in combating the virus.
Used in Hepatotoxicity Research:
2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE is used as a subject of study in research related to acetaminophen-related hepatotoxicity. It has been found to potentially increase hepatotoxicity by enhancing mitochondrial dysfunction, which can be crucial in understanding the drug's side effects and developing safer alternatives.
Check Digit Verification of cas no
The CAS Registry Mumber 7057-48-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,5 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7057-48:
(6*7)+(5*0)+(4*5)+(3*7)+(2*4)+(1*8)=99
99 % 10 = 9
So 7057-48-9 is a valid CAS Registry Number.
7057-48-9Relevant articles and documents
A Highly Stereoselective Synthesis of Anti-HIV 2',3'-Dideoxy- and 2',3'-Didehydro-2',3'-dideoxynucleosides
Beach, J. Warren,Kim, Hea O.,Jeong, Lak S.,Nampalli, Satyanarayana,Islam, Qamrul,et al.
, p. 3887 - 3894 (2007/10/02)
A general total synthesic method for the stereocontrolled synthesis of 2',3'-dideoxy- as well as 2',3'-didehydro-2',3'-dideoxynucleosides is presented.Introduction of an α-phenylselenenyl group at the 2-position of 2,3-dideoxyribosyl acetate directs the glycosyl bond formation to give >/=95percent β-isomer.This 2'-phenylselenenyl nucleoside may be converted to either the 2',3'-dideoxynucleoside by treatment with n-Bu3SnH and Et3B at room temperature or to the unsaturated derivative by treatment with H2O2/cat. pyridine.The application of this method to the syntheses of pyrimidines (ddU, ddT, ddC), 6-substituted purines (ddA, ddI, 6-chloro-ddP, N6-Me-ddA), and 2,6-disubstituted purines (2-F-ddA, 6-chloro-2-amino-ddP) as well as selected 2',3'-didehydro-2',3'-dideoxy derivatives is reported.
