70588-52-2

Basic information

• Product Name: (E)-(1-(2-methylphenyl)-1,2-diphenyl)ethene
• CAS NO: 70588-52-2
• Molecular Weight: 270.374
• Mol File: 70588-52-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: (E)-(1-(2-methylphenyl)-1,2-diphenyl)ethene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(1-(2-methylphenyl)-1,2-diphenyl)ethene(70588-52-2)
• EPA Substance Registry System: (E)-(1-(2-methylphenyl)-1,2-diphenyl)ethene(70588-52-2)

Safety Data

• Hazardous Substances Data: 70588-52-2(Hazardous Substances Data)

Upstream product

• 131-58-8 2-Methylbenzophenone 
• 6921-34-2 benzylmagnesium chloride 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 615-37-2 ortho-methylphenyl iodide 
• 16419-60-6 2-Methylphenylboronic acid 
• 95-46-5 2-methylphenyl bromide 
• 501-65-5 diphenyl acetylene 
• 78578-99-1 (Z)-1-Brom-2-(2-methylphenyl)-1,2-diphenylethen 
• 78579-00-7 (E)-1-Brom-2-(2-methylphenyl)-1,2-diphenylethen 
• 78578-99-1 1-Brom-2-(2-methylphenyl)-1,2-diphenylethen 
• 78579-05-2 (Z)-2-(2-Methylphenyl)-1,2-diphenylvinyllithium 
• 1985-77-9 (Z)-(1-(o-tolyl)ethene-1,2-diyl)dibenzene 
• 70789-12-7 1-(2-Methylphenyl)-1,2-diphenylethanol 
• 78579-03-0 (Z)-1-<2-(Brommethyl)phenyl>-1,2-diphenylethen 

Downstream Products

• 78579-03-0 (Z)-1-<2-(Brommethyl)phenyl>-1,2-diphenylethen 
• 78579-97-2 2-deuterio-4a,5-dihydro-10-phenyl-2H-dibenzocycloheptene 
• 37984-98-8 1-(2-methylphenyl)-1,2-diphenylethane 
• 5324-00-5 2,3-diphenyl-1H-indene 
• 13304-53-5 3-(2-Methylphenyl)-2-phenyl-1H-inden-1-on 
• 18084-10-1 10-phenyl-5H-dibenzo[a,d]cycloheptene 
• 13376-04-0 4-methyl-2,3-diphenyl-1H-inden-1-one 
• 78579-04-1 (Z)-1-<2-(Ethoxymethyl)phenyl>-1,2-diphenylethen 
• 1985-77-9 (Z)-(1-(o-tolyl)ethene-1,2-diyl)dibenzene 
• 1985-77-9 (E)-(1-(2-methylphenyl)-1,2-diphenyl)ethene 
• 78579-05-2 (Z)-2-(2-Methylphenyl)-1,2-diphenylvinyllithium 
• 78579-05-2 (E)-2-(2-Methylphenyl)-1,2-diphenylvinyllithium 
• 78579-00-7 (E)-1-Brom-2-(2-methylphenyl)-1,2-diphenylethen 
• 78578-99-1 (Z)-1-Brom-2-(2-methylphenyl)-1,2-diphenylethen 

Relevant articles and documents

Mizoroki–Heck reaction of 1,2-disubstituted aryl alkenes: Variables of synthesis, solvent and ligand modulation of reactivity

Reaction of aryl iodides with 1,2-disubstituted aryl alkenes in the presence of TBABr/TBACl gave high yields of the Mizoroki–Heck product. Phosphine ligands were used for the modulation of reactivity and stereoselectivity, for the reaction of 4-iodoanisole with cinnamaldehyde. tert-Bu3P.HBF4 gave the highest E:Z ratio of 1:0.08. The use of PEG-200 and PEG-400 as solvent could activate the reaction of aryl iodides with various 1,2-disubstituetd aryl alkenes.

Pd-catalyzed cross-coupling of highly sterically congested enol carbamates with grignard reagents via c-o bond activation

The palladium-catalyzed cross-coupling reaction of enol carbamates to construct highly sterically congested alkenyl compounds is presented for the first time. This protocol demonstrates the potential of using thermally stable and highly atom-economic enol electrophiles as building blocks in bulky alkene synthesis. This reaction accommodates a broad substrate scope with excellent Z/E isomer ratios, which also provides a new synthetic pathway for accessing Tamoxifen.

Nickel-Catalyzed Hydroarylation of Alkynes under Reductive Conditions with Aryl Bromides and Water

An operationally simple nickel-catalyzed hydroarylation reaction for alkynes is described. This three-component coupling reaction utilizes commercially available alkynes and aryl bromides, along with water and Zn. An air-stable and easily synthesized Ni(II) precatalyst is the only entity used in the reaction that is not commercially available. This reductive cross-coupling reaction displays a fairly unusual anti selectivity when aryl bromides with ortho substituents are used. In addition to optimization data and a preliminary substrate scope, complementary experiments including deuterium labeling studies are used to provide a tentative catalytic mechanism. We believe this report should inspire and inform other Ni-catalyzed carbofunctionalization reactions.