70628-24-9

Basic information

• Product Name: Benzoic acid, 4-[2-(diethylamino)ethoxy]-, ethyl ester
• CAS NO: 70628-24-9
• Molecular Formula: C15H23NO3
• Molecular Weight: 265.353
• Mol File: 70628-24-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[2-(diethylamino)ethoxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-(diethylamino)ethoxy]-, ethyl ester(70628-24-9)
• EPA Substance Registry System: Benzoic acid, 4-[2-(diethylamino)ethoxy]-, ethyl ester(70628-24-9)

Safety Data

• Hazardous Substances Data: 70628-24-9(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 141-52-6 sodium ethanolate 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 34329-16-3 4-(2-diethylamino-ethoxy)-benzoic acid 
• 99003-16-4 (2-Diethylamino-ethyl)-<4-(2-diethylamino-ethoxy)-phenylmethyl>-ether 
• 46745-36-2 (4-(2-(diethylamino)ethoxy)phenyl)methan-1-ol 
• 802268-96-8 4-(2-diethylamino-ethoxy)-benzoic acid-(2-diethylamino-ethyl ester) 

Relevant articles and documents

Synthesis of several phenoxymethylphenyl derivatives with local-anesthetic activity

Several 4-phenoxymethyl-procaine derivatives were synthetised in order to investigate the influence of the intermediate chain on the activity. By replacing the CH2-CH2-group in fomocain by a COO-group the authors succeeded in doubling the efficacy of this local anesthetic. The type and position of the hetero atoms, N, S and O, in the intermediate chain of the procain, xylocaine, cinchocaine and phenoxymethyl-procaine series, have in each of these series quite a different effect due to the structureal specificity of the remaining part of the molecule. Other examples confirm the significance of the ester group in the intermediate chain for the liposolubility and reactivity. In ketones these properties are altered unfavourably.