70629-60-6

Basic information

• Product Name: Isopropylhydrazine dihydrochloride
• Synonyms: isopropylhydrazine hydrochloride 2HCL
• CAS NO: 70629-60-6
• Molecular Formula: C₃H₁₀N₂*2ClH
• Molecular Weight: 147.04678
• Mol File: 70629-60-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isopropylhydrazine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropylhydrazine dihydrochloride(70629-60-6)
• EPA Substance Registry System: Isopropylhydrazine dihydrochloride(70629-60-6)

Safety Data

• Hazardous Substances Data: 70629-60-6(Hazardous Substances Data)

Upstream product

• 175233-53-1 1-isopropylhydrazinecarboxylic acid tert-butyl ester 
• 16689-35-3 tert-butyl 2-(isopropyl)hydrazinecarboxylate 
• 1133463-25-8 1-(isopropyl)-2-tert-butoxycarbonylhydrazine acetate 
• 16689-34-2 tert-butyl isopropylidenecarbazate 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 93737-04-3 Z-Leu-HN-NH-CH(CH₃)2 
• 92432-33-2 Z-Ala-HN-NH-CH(CH₃)2 
• 92432-52-5 Z-DL-Ser-HN-NH-CH(CH₃)2 
• 92432-44-5 Z-Sar-HN-NH-CH(CH₃)2 
• 97809-29-5 Z-DL-Glu(NH₂)-HN-NH-CH(CH₃)2 
• 857267-04-0 3-amino-1-(propan-2-yl)-1H-pyrazole 
• 1221503-83-8 5-(4-fluorophenyl)-3-methyl-1-(1-methylethyl)-1H-pyrazole 
• 3544-35-2 2-(4-chlorophenoxy)-N'-isopropylacetohydrazide 
• 956316-85-1 benzyl 3-(2-isopropylhydrazono)propylcarbamate 
• 21254-23-9 5-Amino-4-cyan-1-isopropyl-pyrazol 
• 1221743-48-1 3-(3-nitrobenzyl)-5-amino-1-isopropyl-1H-pyrazole-4-carbonitrile 
• 1219018-67-3 4-(5-amino-4-cyclopropyl-1-isopropyl-1H-pyrazol-3-yl)benzonitrile 
• 1211547-98-6 5-(4-bromo-phenyl)-1-isopropyl-3-methyl-1H-[1,2,4]triazole 
• 1211547-94-2 2-(1-isopropyl-3-phenyl-1H-1,2,4-triazol-5-yl)pyrazine 

Relevant articles and documents

Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis

We report the cerium photocatalyzed radical decarboxylative hydrazination of carboxylic acids with di-tert-butylazodicarboxylate (DBAD). The operationally simple protocol provides rapid access to synthetically useful hydrazine derivatives and overcomes current scope limitations in the photoredox-catalyzed decarboxylation of carboxylic acids.

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors

The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PDE9 INHIBITORS

A compound of the general formula (I) wherein R1 is selected from the group consisting of phenyl unsubstituted or substituted with 1 to 3 substituents selected from F, Cl, Br, I, CN, -O-C1-C3-alkyl, fluorinated -O-C1-C3-alkyl, -(CH2)mOH and 5-membered heterocyclic group with 1 or 2 heteroatoms selected from N, O and S; and 6- or 10-membered heteroaryl with 1 to 3 heteroatoms selected from O, N and S; R2 and R3 independently of each other represent H atom or straight or branched C1-C3 alkyl; R4 is selected from the group consisting of 4- to 6- membered cycloalkyl, wherein one of carbon atoms can be replaced by O atom, and which is unsubstituted or substituted with one or two halogen atoms,and straight or branched C1-C4 alkyl; Q represents a bond or C1-C3-alkylene, which can be optionally substituted by one to three C1-C3-alkyls; X is selected from the group consisting of O, NR5, and S(O)p; R5 represents H atom or C1-C3alkyl; m is 1, 2 or 3; p is 0, 1 or 2; and salts thereof, for use as a medicament, in particular for treating cognitive function disorders and neurodegenerative diseases.