70667-26-4 Usage
Description
Ornoprostil is a prostaglandin-based antiulcer agent that is structurally related to alprostadil, enprostil, and misoprostol. It is reportedly useful in the treatment of gastric ulcers.
Used in Pharmaceutical Industry:
Ornoprostil is used as an antiulcer agent for the treatment of gastric ulcers, providing relief and promoting healing of the affected areas.
Used in Immunosuppressive Pharmaceutical Composition:
Ornoprostil is used as an immunosuppressive agent in pharmaceutical compositions, helping to modulate the immune response and potentially managing autoimmune conditions or preventing transplant rejection.
Originator
Ono (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 70667-26-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,6,6 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 70667-26:
(7*7)+(6*0)+(5*6)+(4*6)+(3*7)+(2*2)+(1*6)=134
134 % 10 = 4
So 70667-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H38O6/c1-4-5-8-16(2)13-18(25)11-12-19-20(22(27)15-21(19)26)14-17(24)9-6-7-10-23(28)29-3/h11-12,16,18-21,25-26H,4-10,13-15H2,1-3H3/b12-11+/t16-,18+,19+,20+,21+/m0/s1
70667-26-4Relevant articles and documents
Synthesis of the key component for preparation of 6-ketoprostaglandins by a two-component coupling process: Synthesis of 6-keto-prostaglandin E1, ornoprostil and Δ2-trans-6-ketoprostaglandin E1
Kawanaka, Yasufumi,Ono, Naoya,Yoshida, Yukio,Okamoto, Sentaro,Sato, Fumie
, p. 715 - 718 (2007/10/03)
Starting with commercially available (3S,4R)-3-(methoxymethyloxy)-2-methylidene-4-siloxycyclopentanone 2, useful 6-keto-prostaglandin intermediates 1 have been prepared in good yields by a sequence of reactions which includes treatment with NaBr in the presence of BF3·OEt2, Pd-catalysed coupling of the resulting 2-bromomethyl-4-siloxycyclopent-2-enone 3 with the alkenylborane 4 or 9 and conversion of the alkenyl moiety into an epoxy and then into a keto group. The synthesis of 6-keto-PGE1, ornoprostil and Δ2-trans-6-keto-PGE1 by using 1 is also described.