706789-13-1Relevant articles and documents
4-Bromomethyl-2-chlorooxazole - A versatile oxazole cross-coupling unit for the synthesis of 2,4-disubstituted oxazoles
Young, Gail L.,Smith, Stephen A.,Taylor, Richard J.K.
, p. 3797 - 3801 (2007/10/03)
The synthesis of the novel oxazole building block, 4-bromomethyl-2- chlorooxazole, and its palladium-catalysed cross-coupling reactions to make a range of 2,4-disubstituted oxazoles, is described. Selectivity for the 4-bromomethyl position is observed, with Stille coupling effected in good to excellent yields, or Suzuki coupling in moderate yields, to provide a range of 4-substituted-2-chlorooxazoles. Subsequent coupling at the 2-chloro-position can be achieved through either Stille or Suzuki reactions in excellent yields.
